Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex.
about
New Insights into How Trafficking Regulates T Cell Receptor SignalingCytotoxic granule secretion by lymphocytes and its link to immune homeostasisCell biological steps and checkpoints in accessing NK cell cytotoxicityCell polarisation and the immunological synapseRegulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectorsMEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesisHDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes.Evidence for defective Rab GTPase-dependent cargo traffic in immune disorders.Cytokine Secretion in Macrophages: SNAREs, Rabs, and Membrane Trafficking.Immune synapse: conductor of orchestrated organelle movement.HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing.Human NK cell lytic granules and regulation of their exocytosisLysosome-related organelles: unusual compartments become mainstream.Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex.Follistatin-like protein 1 and the ferritin/erythrocyte sedimentation rate ratio are potential biomarkers for dysregulated gene expression and macrophage activation syndrome in systemic juvenile idiopathic arthritis.Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity.NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing.Familial hemophagocytic lymphohistiocytosis: when rare diseases shed light on immune system functioning.The function of sub-synaptic vesicles during T-cell activation.New views of the human NK cell immunological synapse: recent advances enabled by super- and high-resolution imaging techniques.Rab27 effectors, pleiotropic regulators in secretory pathways.Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses.The central role of the cytoskeleton in mechanisms and functions of the NK cell immune synapse.The newly found functions of MTOC in immunological response.Activation of Lymphocyte Cytolytic Machinery: Where are We?In the crosshairs: investigating lytic granules by high-resolution microscopy and electrophysiology.A unique SNARE machinery for exocytosis of cytotoxic granules and platelets granules.Origins of the cytolytic synapse.HDAC6 is a Regulator of CTL Function through Control of Lytic Granule Dynamics.Mechanisms and functions of lysosome positioning.Rabs set the stage for polarity.Moving and positioning the endolysosomal system.NK cell lytic granules are highly motile at the immunological synapse and require F-actin for post-degranulation persistence.Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with CiliogenesisEnteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restorationOrchestrating Lymphocyte Polarity in Cognate Immune Cell-Cell Interactions.Signals Controlling Lytic Granule Polarization at the Cytotoxic Immune Synapse.Sailing to and Docking at the Immune Synapse: Role of Tubulin Dynamics and Molecular Motors.
P2860
Q26742022-6D16FF78-566B-4263-A76F-791028EC0D31Q26776499-0FF60B00-FB0A-4AAD-8EFA-ADFAC7963926Q26852411-D6288387-FFD7-4B3D-8C3F-86F1DB78D591Q26862236-D27CCAE6-A0CC-4284-A32B-F7FFF918F587Q27012658-6E925571-CB04-4BF9-993C-9B0D58EC6A0FQ27331832-153C01E5-9872-4DA4-AA1D-B1A97DC1FEDEQ28115598-3E825134-C9E6-4BEB-8BA4-10AE5C170527Q30811074-D27AE70A-15C3-4F03-99E4-241B3847ED65Q33408755-E35C42C6-97EA-45E8-908E-A5A5F6EE54A1Q34406845-67FB7862-FBDC-4A94-8DF5-BB31D56A98C5Q35141243-57A00E5C-F3AD-4F29-A927-85FEFC08C938Q35575540-9258B8CE-09E8-4F76-B271-0129AD79E4B1Q36386541-C054A457-08D7-4A47-832A-1E3D866B3296Q37060715-7B63C425-1DA8-40F3-8DB8-BB3064C2AB52Q37348756-B0926461-DF2A-45D5-867C-C948DED8303CQ37375203-9E64E5DF-CDAA-4359-8130-4A95EF65D69BQ37451624-2846AA95-351A-4A15-812E-9DA6460D1116Q37497535-9756962B-E206-4CBD-8A76-B6C4CB8F18CDQ37513964-B43903A1-34DD-4624-91BE-0921A2769A50Q37719014-EB3136A3-0D35-4447-9E46-036F4F4A9EEDQ38070786-3AEE08F1-2CB2-4A85-A004-92B18DA6AFACQ38073764-ABE70744-D88C-4815-BC8A-35F3FE994955Q38107224-509808E0-D6C8-4210-A610-A9479C3753E4Q38151848-4233D70E-C05A-4EB5-8250-D9BC0AEAC0E6Q38151853-9685B6E8-1C82-43D5-9523-4B806C4093EAQ38167946-082A5204-AEF1-49C5-89E4-AC9CEB863F07Q38169149-D30317B0-6DF0-4F67-A0FB-2312F8C1BD38Q38172133-629D681B-8145-4A35-B210-76A9EB9D9A59Q38618050-D81F0E83-F47B-4F87-BCBB-73E3C5B9FF89Q38856011-EC3DC442-7AC4-4C37-9D4A-9425901B353BQ38946427-1D520476-CAE4-4B59-B228-22FD6482216EQ38995568-41B22248-7ED2-4A6C-9753-E859DFB6F7D1Q39104860-891A2031-B9DA-4965-8A1F-D73C8F3CDECCQ39148157-C9E9426D-66B1-46A3-B14C-06DB3154DA75Q39259156-08EA2810-C4C5-4949-9112-A59FA46A5A01Q40869930-D2BD4FCD-6F22-43E5-82CD-62E7C24CB6AEQ41506828-34E18AB6-CDCB-4E56-9BEC-5F4E4DF92C17Q41928606-7B2A916C-C454-4125-B0F2-28C731178D54Q52668321-D413886C-58AC-4E5D-8D8B-AAD1240FA156Q55119821-C9951EE6-D4F4-4FF3-861B-024F15EEDD92
P2860
Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Terminal transport of lytic gr ...... kinesin-1/Slp3/Rab27a complex.
@en
Terminal transport of lytic gr ...... kinesin-1/Slp3/Rab27a complex.
@nl
type
label
Terminal transport of lytic gr ...... kinesin-1/Slp3/Rab27a complex.
@en
Terminal transport of lytic gr ...... kinesin-1/Slp3/Rab27a complex.
@nl
prefLabel
Terminal transport of lytic gr ...... kinesin-1/Slp3/Rab27a complex.
@en
Terminal transport of lytic gr ...... kinesin-1/Slp3/Rab27a complex.
@nl
P2093
P2860
P50
P1433
P1476
Terminal transport of lytic gr ...... kinesin-1/Slp3/Rab27a complex.
@en
P2093
Alain Fischer
Magali Court
Mathieu Kurowska
Nadine T Nehme
Nicolas Goudin
P2860
P304
P356
10.1182/BLOOD-2011-09-382556
P407
P577
2012-02-03T00:00:00Z