Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition. - Wikidata - awgldk - TriplyDB

Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition.

Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition.

http://www.wikidata.org/entity/Q42919170

about

RhoA: a therapeutic target for chronic myeloid leukemia Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF Epithelial-mesenchymal transition and its implications for fibrosis Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam Dynamic functions of RhoA in tumor cell migration and invasion RhoE binds to ROCK I and inhibits downstream signaling The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways Cortical factor feedback model for cellular locomotion and cytofission Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1 Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway RAS oncogenes: weaving a tumorigenic web PAK1 negatively regulates the activity of the Rho exchange factor NET1 Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD Evidence that fibroblasts derive from epithelium during tissue fibrosis The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity.Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration.Beta8 integrin binds Rho GDP dissociation inhibitor-1 and activates Rac1 to inhibit mesangial cell myofibroblast differentiation.Restoration of E-cadherin cell-cell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in Ras-transformed breast epithelial cells.Integrin-dependent actomyosin contraction regulates epithelial cell scattering.Localized RhoA activation as a requirement for the induction of membrane ruffling.Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases Vimentin is involved in regulation of mitochondrial motility and membrane potential by Rac1.Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation.R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2.Pitx2a expression alters actin-myosin cytoskeleton and migration of HeLa cells through Rho GTPase signaling Cadherin and catenin alterations in human cancer.The effect of statin on epithelial-mesenchymal transition in peritoneal mesothelial cells.Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma.Interplay of RhoA and motility in the programmed spreading of daughter cells postmitosis Genetic evidence for antagonism between Pak protein kinase and Rho1 small GTPase signaling in regulation of the actin cytoskeleton during Drosophila oogenesis.The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4.

P2860

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P2860

Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition.

http://www.wikidata.org/entity/Q42919170

description

2000 nî lūn-bûn

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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2000年论文

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2000年论文

@zh-cn

name

Oncogenic Ras downregulates Ra ...... helial-mesenchymal transition.

@en

Oncogenic Ras downregulates Ra ...... helial-mesenchymal transition.

@nl

type

label

Oncogenic Ras downregulates Ra ...... helial-mesenchymal transition.

@en

Oncogenic Ras downregulates Ra ...... helial-mesenchymal transition.

@nl

prefLabel

Oncogenic Ras downregulates Ra ...... helial-mesenchymal transition.

@en

Oncogenic Ras downregulates Ra ...... helial-mesenchymal transition.

@nl

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P1433

Journal of Cell Biology

P1476

Oncogenic Ras downregulates Ra ...... helial-mesenchymal transition.

@en

P2093

E E Evers

http://www.w3.org/2001/XMLSchema#string

G C Zondag

http://www.w3.org/2001/XMLSchema#string

J G Collard

http://www.w3.org/2001/XMLSchema#string

J P ten Klooster

http://www.w3.org/2001/XMLSchema#string

L Janssen

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R A van der Kammen

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P2860

Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia

Regulation of cell motility by mitogen-activated protein kinase

Rho GTPases and the actin cytoskeleton

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

EPS8 and E3B1 transduce signals from Ras to Rac

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion

Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42

P304

775-782

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scholarly article

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10.1083/JCB.149.4.775

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4

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149

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277521311

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10811819

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2174558

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