SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase.
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Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and ResistanceBinding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase InhibitorsStructure-function relationships among RNA-dependent RNA polymerases1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside InhibitorsFocus on flaviviruses: current and future drug targetsThe HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase functionCovalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition ReactionsStructure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase.Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidaseDesign of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation.A small molecule screen identifies selective inhibitors of urea transporter UT-A.A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline.Thiazolidinedione-based PI3Kα inhibitors: an analysis of biochemical and virtual screening methods.Classification of HCV NS5B polymerase inhibitors using support vector machine.Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors.Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase.Inhibitors for the hepatitis C virus RNA polymerase explored by SAR with advanced machine learning methods.Design, synthesis, and biological evaluation of N-carboxyphenylpyrrole derivatives as potent HIV fusion inhibitors targeting gp41Structure-activity relationships in the development of allosteric hepatitis C virus RNA-dependent RNA polymerase inhibitors: ten years of research.Novel 4-thiazolidinones as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.Targeting biomolecules with reversible covalent chemistrySelective killing of nonreplicating mycobacteria.Covalent docking using autodock: Two-point attractor and flexible side chain methods.Observations on screening-based research and some concerning trends in the literature.(5S)-5-Methyl-3-phenyl-2-sulfanyl-idene-1,3-thia-zolidin-4-one.Ultrasound-assisted synthesis of 2,4-thiazolidinedione and rhodanine derivatives catalyzed by task-specific ionic liquid: [TMG][Lac]Quantitative structure and bioactivity relationship study on HCV NS5B polymerase inhibitors.Combined 3D-QSAR, molecular docking, molecular dynamics simulation, and binding free energy calculation studies on the 5-hydroxy-2H-pyridazin-3-one derivatives as HCV NS5B polymerase inhibitors.CovalentDock: automated covalent docking with parameterized covalent linkage energy estimation and molecular geometry constraints.Development of supercritical fluid extraction and supercritical fluid chromatography purification methods using rapid solubility screening with multiple solubility chambers.Recent developments with rhodanine as a scaffold for drug discovery.Tertiary amine-catalyzed and direct synthesis of α-chloroalkanesulfonylhydrazines from azodicarboxylates and sulfonyl chlorides.New 5-ylidene rhodanine derivatives based on the dispacamide A model.An efficient and green procedure for synthesis of rhodanine derivatives by aldol-thia-Michael protocol using aqueous diethylamine mediumBaseline dasabuvir resistance in Hepatitis C virus from the genotypes 1, 2 and 3 and modeling of the NS5B-dasabuvir complex by the approach
P2860
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P2860
SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
SAR and mode of action of nove ...... patitis C NS5b RNA polymerase.
@en
SAR and mode of action of nove ...... patitis C NS5b RNA polymerase.
@nl
type
label
SAR and mode of action of nove ...... patitis C NS5b RNA polymerase.
@en
SAR and mode of action of nove ...... patitis C NS5b RNA polymerase.
@nl
prefLabel
SAR and mode of action of nove ...... patitis C NS5b RNA polymerase.
@en
SAR and mode of action of nove ...... patitis C NS5b RNA polymerase.
@nl
P2093
P356
P1476
SAR and mode of action of nove ...... patitis C NS5b RNA polymerase.
@en
P2093
Derek E Piper
George R Tonn
James M Chen
Jay P Powers
Jinqian Liu
John Anzola
Juan C Jaen
M Greg Peterson
Nigel P C Walker
P304
P356
10.1021/JM050859X
P407
P577
2006-02-01T00:00:00Z