Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons.
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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down SyndromeGSK-3: Functional Insights from Cell Biology and Animal Models.Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc.Phosphorylation by Dyrk1A of clathrin coated vesicle-associated proteins: identification of the substrate proteins and the effects of phosphorylation.SILAC-based quantitative proteomic analysis of human lung cell response to copper oxide nanoparticles.Nanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B.Drebrin contains a cryptic F-actin-bundling activity regulated by Cdk5 phosphorylation.What Are the bona fide GSK3 Substrates?The role of microtubule-associated protein 1B in axonal growth and neuronal migration in the central nervous system.Modeling the functional genomics of autism using human neurons.DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3Microtubule stability, Golgi organization, and transport flux require dystonin-a2-MAP1B interaction.Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3β to A-kinase Anchoring Protein 220Specific serine-proline phosphorylation and glycogen synthase kinase 3β-directed subcellular targeting of stathmin 3/Sclip in neurons.Ten new cases further delineate the syndromic intellectual disability phenotype caused by mutations in DYRK1A.Large scale phosphoproteome analysis of LNCaP human prostate cancer cellsUsp14 deficiency increases tau phosphorylation without altering tau degradation or causing tau-dependent deficits.New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down SyndromeIntracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A).Activation, regulation, and inhibition of DYRK1A.MNB/DYRK1A as a multiple regulator of neuronal development.The MAP1B case: an old MAP that is new again.Importance of gene dosage in controlling dendritic arbor formation during development.Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity.RNA-binding proteins of the NXF (nuclear export factor) family and their connection with the cytoskeleton.Autism genetics - an overview.Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology.Depletion of JMJD5 sensitizes tumor cells to microtubule-destabilizing agents by altering microtubule stability.Collapsin response mediator proteins (CRMPs) are a new class of microtubule-associated protein (MAP) that selectively interacts with assembled microtubules via a taxol-sensitive binding interaction.Sustained GSK3 activity markedly facilitates nerve regeneration.Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans.ReMAPping the microtubule landscape: How phosphorylation dictates the activities of microtubule-associated proteins.Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development.Collapsin response-mediator protein 5 (CRMP5) phosphorylation at threonine 516 regulates neurite outgrowth inhibition.Dyrk1A influences neuronal morphogenesis through regulation of cytoskeletal dynamics in mammalian cortical neurons.Evolution of the spatial distribution of MAP1B phosphorylation sites in vertebrate neurons.MAP1B mutations cause intellectual disability and extensive white matter deficitCorrection of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A
P2860
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P2860
Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Nonprimed and DYRK1A-primed GS ...... ule dynamics in growing axons.
@en
Nonprimed and DYRK1A-primed GS ...... ule dynamics in growing axons.
@nl
type
label
Nonprimed and DYRK1A-primed GS ...... ule dynamics in growing axons.
@en
Nonprimed and DYRK1A-primed GS ...... ule dynamics in growing axons.
@nl
prefLabel
Nonprimed and DYRK1A-primed GS ...... ule dynamics in growing axons.
@en
Nonprimed and DYRK1A-primed GS ...... ule dynamics in growing axons.
@nl
P2093
P2860
P356
P1476
Nonprimed and DYRK1A-primed GS ...... bule dynamics in growing axons
@en
P2093
Michaela Kraus
Robert G Goold
Timothy M E Scales
P2860
P304
P356
10.1242/JCS.040162
P407
P577
2009-06-23T00:00:00Z