A negative feedback signaling network underlies oncogene-induced senescence. - Wikidata - awgldk - TriplyDB

A negative feedback signaling network underlies oncogene-induced senescence.

A negative feedback signaling network underlies oncogene-induced senescence.

http://www.wikidata.org/entity/Q43116108

about

A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas Autophagy mediates the mitotic senescence transition Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma Cellular senescence controls fibrosis in wound healing Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs)MAPK pathway activation in pilocytic astrocytoma Pathological and molecular advances in pediatric low-grade astrocytoma Elucidating distinct roles for NF1 in melanomagenesis Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.Redox control of senescence and age-related disease Epigenetic mechanisms drive the progression of neurofibromas to malignant peripheral nerve sheath tumors Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer BRAF vs RAS oncogenes: are mutations of the same pathway equal? Differential signalling and therapeutic implications Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape The senescence-associated secretory phenotype: the dark side of tumor suppression Cooperation between Noncanonical Ras Network Mutations.Therapeutic advances for the tumors associated with neurofibromatosis type 1, type 2, and schwannomatosis NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2.Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms Microfluidic probe for single-cell analysis in adherent tissue culture.Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner.Unexpected pieces to the senescence puzzle A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila.The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence.PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling Minireview: physiological and pathological actions of RAS in the ovary.Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells.

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P2860

A negative feedback signaling network underlies oncogene-induced senescence.

http://www.wikidata.org/entity/Q43116108

description

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2006年學術文章

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name

A negative feedback signaling network underlies oncogene-induced senescence.

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A negative feedback signaling network underlies oncogene-induced senescence.

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type

label

A negative feedback signaling network underlies oncogene-induced senescence.

@en

A negative feedback signaling network underlies oncogene-induced senescence.

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prefLabel

A negative feedback signaling network underlies oncogene-induced senescence.

@en

A negative feedback signaling network underlies oncogene-induced senescence.

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A negative feedback signaling network underlies oncogene-induced senescence.

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Bryan W Johnson

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Cory M Johannessen

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Elizabeth E Reczek

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Karen Cichowski

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Lauren T McGillicuddy

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Mia MacCollin

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Pablo E Hollstein

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Stéphanie Courtois-Cox

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Sybil M Genther Williams

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P2860

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Targeting RAS signalling pathways in cancer therapy

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

NF1 tumor suppressor gene function: narrowing the GAP

Developmental regulation and overexpression of the transcription factor AP-2, a potential regulator of the timing of Schwann cell generation

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

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