Relationship between drug/metabolite exposure and impairment of excretory transport function. - Wikidata - awgldk - TriplyDB

Relationship between drug/metabolite exposure and impairment of excretory transport function.

Relationship between drug/metabolite exposure and impairment of excretory transport function.

http://www.wikidata.org/entity/Q43129920

about

ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans Membrane transporters in drug development Predicting the outer boundaries of P-glycoprotein (P-gp)-based drug interactions at the human blood-brain barrier based on rat studies.Pitavastatin is a more sensitive and selective organic anion-transporting polypeptide 1B clinical probe than rosuvastatin.Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver.Trimethoprim-metformin interaction and its genetic modulation by OCT2 and MATE1 transporters.Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver.An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown.Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: it's not just about OATP1B1.Species differences in drug transporters and implications for translating preclinical findings to humans.Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position.Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved.Mechanisms and therapeutic potential of inhibiting drug efflux transporters.A Comprehensive Review of Drug-Drug Interactions with Metformin.The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy.Fractional dynamics pharmacokinetics-pharmacodynamic models.The elimination of MTC-220, a novel anti-tumor agent of conjugate of paclitaxel and muramyl dipeptide analogue, in rats.Cellular Pharmacokinetic Model-Based Analysis of Genistein, Glyceollin, and MK-571 Effects on 5 (and 6)-Carboxy-2',7'-Dichloroflourescein Disposition in Caco-2 Cells.Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1).Role of Hepatic Drug Transporters in Drug Development.

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P2860

Relationship between drug/metabolite exposure and impairment of excretory transport function.

http://www.wikidata.org/entity/Q43129920

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

@zh-my

2008年学术文章

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2008年學術文章

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2008年學術文章

@zh-hant

name

Relationship between drug/meta ...... excretory transport function.

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Relationship between drug/meta ...... excretory transport function.

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type

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Relationship between drug/meta ...... excretory transport function.

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Relationship between drug/meta ...... excretory transport function.

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Relationship between drug/meta ...... excretory transport function.

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Relationship between drug/meta ...... excretory transport function.

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Drug Metabolism and Disposition

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Relationship between drug/meta ...... f excretory transport function

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P2093

Gary M Pollack

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J Cory Kalvass

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Maciej J Zamek-Gliszczynski

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P2860

Inhibition of biliary excretion of methotrexate by probenecid in rats: quantitative prediction of interaction from in vitro data.

Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans.

Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites.

An integrated approach to model hepatic drug clearance.

Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment.

Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2)

Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats.

Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice.

Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats.

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386-390

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scholarly article

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10.1124/DMD.108.023648

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2

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19022942

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2680528

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