Novel oximes as blood-brain barrier penetrating cholinesterase reactivators.

Novel oximes as blood-brain barrier penetrating cholinesterase reactivators.

Item
http://www.wikidata.org/entity/Q43130695
A conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oximeMechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugatesNew structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases.Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.Chronic Treatment with Naltrexone Prevents Memory Retention Deficits in Rats Poisoned with the Sarin Analog Diisopropylfluorophosphate (DFP) and Treated with Atropine and PralidoximeMini review on blood-brain barrier penetration of pyridinium aldoximes.Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems.Post-exposure treatment with the oxime RS194B rapidly reverses early and advanced symptoms in macaques exposed to sarin vapor.SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides.Translation of in vitro to in vivo pyridinium oxime potential in tabun poisoning.Time-dependent changes of oxime K027 concentrations in different parts of rat central nervous system.The biodistribution and pharmacokinetics of the oxime acetylcholinesterase reactivator RS194B in guinea pigs.
P2860

Novel oximes as blood-brain barrier penetrating cholinesterase reactivators.

Item
http://www.wikidata.org/entity/Q43130695
description
2010 nî lūn-bûn
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
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2010年學術文章
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2010年學術文章
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name
Novel oximes as blood-brain barrier penetrating cholinesterase reactivators.
@en
Novel oximes as blood-brain barrier penetrating cholinesterase reactivators.
@nl
type
label
Novel oximes as blood-brain barrier penetrating cholinesterase reactivators.
@en
Novel oximes as blood-brain barrier penetrating cholinesterase reactivators.
@nl
prefLabel
Novel oximes as blood-brain barrier penetrating cholinesterase reactivators.
@en
Novel oximes as blood-brain barrier penetrating cholinesterase reactivators.
@nl
P1433
P1476
P2093
P304
P31
P356
P433
P478
P577
P698
P921
P356
P1433
P1476
Novel oximes as blood-brain barrier penetrating cholinesterase reactivators.
@en
P2093
P304
P31
P356
P433
P478
P577
P698
P921