Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor.
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Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes.General anaesthetic actions on ligand-gated ion channelsInternational Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. UpdateAn initiator element mediates autologous downregulation of the human type A gamma -aminobutyric acid receptor beta 1 subunit geneThe anti-convulsant stiripentol acts directly on the GABA(A) receptor as a positive allosteric modulatorThe interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acidMolecular targets underlying general anaesthesiaPropofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channelsMapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogueEffects of gamma-HCH and delta-HCH on human recombinant GABA(A) receptors: dependence on GABA(A) receptor subunit combinationMutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anestheticsFragrant dioxane derivatives identify beta1-subunit-containing GABAA receptorsIn the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cellsGamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activityLimiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia.Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors.Molecular tools for GABAA receptors: High affinity ligands for β1-containing subtypes.Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacologyThe general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABAA receptor-mediated inhibitionIonotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones.Increases in [3H]muscimol and [3H]flumazenil binding in the dorsolateral prefrontal cortex in schizophrenia are linked to α4 and γ2S mRNA levels respectively.Melatonin and anesthesia: a clinical perspective.A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude)11β-Hydroxylase inhibitors protect against seizures in mice by increasing endogenous neurosteroid synthesis.Clinical and molecular pharmacology of etomidate.Iatrogenic risk factors for Alzheimer's disease: surgery and anesthesia.Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.Mode of action of ICS 205,930, a novel type of potentiator of responses to glycine in rat spinal neurones.Dual mode of stimulation by the beta-carboline ZK 91085 of recombinant GABA(A) receptor currents: molecular determinants affecting its actionThymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABA(A) receptors and a homo-oligomeric GABA receptor from Drosophila melanogasterSalicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors.p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.GABA(A) Receptor β3 Subunit Expression Regulates Tonic Current in Developing Striatopallidal Medium Spiny Neurons.Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes.2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors.Flavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptors.Identification and characterization of anesthetic targets by mouse molecular genetics approaches.Mutations in the GABAA receptor that mimic the allosteric ligand etomidate.Carboetomidate inhibits alpha4/beta2 neuronal nicotinic acetylcholine receptors at concentrations affecting animalsGABAB Receptors Regulate Extrasynaptic GABAA Receptors.
P2860
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P2860
Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Subunit-dependent interaction ...... obutyric acid type A receptor.
@en
Subunit-dependent interaction ...... obutyric acid type A receptor.
@nl
type
label
Subunit-dependent interaction ...... obutyric acid type A receptor.
@en
Subunit-dependent interaction ...... obutyric acid type A receptor.
@nl
prefLabel
Subunit-dependent interaction ...... obutyric acid type A receptor.
@en
Subunit-dependent interaction ...... obutyric acid type A receptor.
@nl
P2093
P2860
P356
P1476
Subunit-dependent interaction ...... obutyric acid type A receptor.
@en
P2093
Hill-Venning C
Lambert JJ
P2860
P304
P356
10.1038/SJ.BJP.0700927
P407
P577
1997-03-01T00:00:00Z