Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.
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Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptorsStructure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic KetamineMultisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channelDrug elucidation: invertebrate genetics sheds new light on the molecular targets of CNS drugs.Mutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anestheticsEfficient modulation of γ-aminobutyric acid type A receptors by piperine derivatives.A membrane-embedded pathway delivers general anesthetics to two interacting binding sites in the Gloeobacter violaceus ion channel.The location and nature of general anesthetic binding sites on the active conformation of firefly luciferase; a time resolved photolabeling study.Atomistic insights into human Cys-loop receptors by solution NMR.Atomistic models of general anesthetics for use in in silico biological studiesStructural basis for alcohol modulation of a pentameric ligand-gated ion channelDodecyl maltopyranoside enabled purification of active human GABA type A receptors for deep and direct proteomic sequencingPositive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Isoflurane alters the structure and dynamics of GLIC.Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion ChannelDirect Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.NMR resolved multiple anesthetic binding sites in the TM domains of the α4β2 nAChRCommon Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion ChannelsAsymmetric ligand binding facilitates conformational transitions in pentameric ligand-gated ion channels.Stabilization of the GluCl ligand-gated ion channel in the presence and absence of ivermectinInhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sitesCysteine substitutions define etomidate binding and gating linkages in the α-M1 domain of γ-aminobutyric acid type A (GABAA) receptorsAssessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor.Neonatal Propofol and Etomidate Exposure Enhance Inhibitory Synaptic Transmission in Hippocampal Cornus Ammonis 1 Pyramidal Neurons.Human α1β3γ2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state.Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.Etomidate produces similar allosteric modulation in α1β3δ and α1β3γ2L GABA(A) receptors.Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.Plant-derived extracts in the neuroscience of anxiety on animal models: biases and comments.The discovery of new anesthetics by targeting GABA(A) receptors.Conformational selection or induced fit? 50 years of debate resolved.Pentameric Ligand-gated Ion Channels : Insights from Computation.Orthosteric- versus allosteric-dependent activation of the GABAA receptor requires numerically distinct subunit level rearrangements.Mapping General Anesthetic Sites in Heteromeric γ-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes.Immune Modulation by Volatile AnestheticsIdentification of a putative binding site critical for general anesthetic activation of TRPA1.Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What?Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.
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P2860
Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Anesthetic sites and allosteri ...... oop ligand-gated ion channels.
@ast
Anesthetic sites and allosteri ...... oop ligand-gated ion channels.
@en
type
label
Anesthetic sites and allosteri ...... oop ligand-gated ion channels.
@ast
Anesthetic sites and allosteri ...... oop ligand-gated ion channels.
@en
prefLabel
Anesthetic sites and allosteri ...... oop ligand-gated ion channels.
@ast
Anesthetic sites and allosteri ...... oop ligand-gated ion channels.
@en
P2860
P1476
Anesthetic sites and allosteri ...... oop ligand-gated ion channels.
@en
P2093
Keith W Miller
Stuart A Forman
P2860
P2888
P304
P356
10.1007/S12630-010-9419-9
P577
2011-01-07T00:00:00Z