Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. - Wikidata - awgldk - TriplyDB

Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse.

Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse.

http://www.wikidata.org/entity/Q43186964

about

Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling Quantitative challenges in understanding ligand discrimination by alphabeta T cells The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells T cell antigen recognition at the cell membrane Structural Basis of the CD8 /MHC Class I Interaction: Focused Recognition Orients CD8 to a T Cell Proximal Position Understanding FRET as a research tool for cellular studies In vivo polarization of IFN-gamma at Kupfer and non-Kupfer immunological synapses during the clearance of virally infected brain cells.Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects.Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function.T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury.NSOM/QD-based direct visualization of CD3-induced and CD28-enhanced nanospatial coclustering of TCR and coreceptor in nanodomains in T cell activation.The impact of TCR-binding properties and antigen presentation format on T cell responsiveness.Epitope density influences CD8+ memory T cell differentiation.High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics.Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection.Intravital imaging of anti-tumor immune response and the tumor microenvironment.Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling.Different domains of the AMPA receptor direct stargazin-mediated trafficking and stargazin-mediated modulation of kinetics.Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor Signaling in thymic selection.Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8.Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells.Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells.Protein kinase C η is required for T cell activation and homeostatic proliferation.CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I.Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module.In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state Purely stochastic binary decisions in cell signaling models without underlying deterministic bistabilities.Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters.Modulation of MHC binding by lateral association of TCR and coreceptor.T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity.Human major histocompatibility complex (MHC) class I molecules with disulfide traps secure disease-related antigenic peptides and exclude competitor peptides A role for "self" in T-cell activation Functional development of the T cell receptor for antigen Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules.Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC.

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P2860

Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse.

http://www.wikidata.org/entity/Q43186964

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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Nonstimulatory peptides contri ...... at the immunological synapse.

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Nonstimulatory peptides contri ...... at the immunological synapse.

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Nonstimulatory peptides contri ...... at the immunological synapse.

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Nature Immunology

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Nonstimulatory peptides contri ...... at the immunological synapse.

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Jeanette Ampudia

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Pia P Yachi

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Tomasz Zal

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P2860

Staging and resetting T cell activation in SMACs

CD3 delta establishes a functional link between the T cell receptor and CD8

Three-dimensional segregation of supramolecular activation clusters in T cells

Phenotypic analysis of antigen-specific T lymphocytes

Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5

Rare, structurally homologous self-peptides promote thymocyte positive selection.

Physical association of CD4 and the T-cell receptor can be induced by anti-T-cell receptor antibodies

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains.

Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells.

The immunological synapse.

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785-792

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Nicholas R J Gascoigne

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7762689

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15980863

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1352171

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