Rationally designed integrin beta3 mutants stabilized in the high affinity conformation.
about
α(V)β(3) integrin crystal structures and their functional implicationsComplete integrin headpiece opening in eight stepsPathogenic hantaviruses direct the adherence of quiescent platelets to infected endothelial cells.Acidic extracellular pH promotes activation of integrin α(v)β(3).A generic program for multistate protein design.Pathogenic hantaviruses Andes virus and Hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cellsRequirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2.Modulation of integrin activation by an entropic spring in the {beta}-kneeIdentification of interacting hot spots in the beta3 integrin stalk using comprehensive interface designVariation in one residue associated with the metal ion-dependent adhesion site regulates αIIbβ3 integrin ligand binding affinity.Identification of integrin beta subunit mutations that alter affinity for extracellular matrix ligand.Reconstruction of integrin activation.The unique disulfide bond-stabilized W1 β4-β1 loop in the α4 β-propeller domain regulates integrin α4β7 affinity and signaling.Integrin activation dynamics between the RGD-binding site and the headpiece hinge.Glycoprotein IIb/IIIa inhibitors: an update on the mechanism of action and use of functional testing methods to assess antiplatelet efficacy.Mutagenesis studies of the β I domain metal ion binding sites on integrin αVβ3 ligand binding affinity.The Role of the Endothelium in HPS Pathogenesis and Potential Therapeutic Approaches.Structural and functional aspects of decorsin and its analog as recognized by integrin αIIbβ3.
P2860
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P2860
Rationally designed integrin beta3 mutants stabilized in the high affinity conformation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Rationally designed integrin beta3 mutants stabilized in the high affinity conformation.
@en
Rationally designed integrin beta3 mutants stabilized in the high affinity conformation.
@nl
type
label
Rationally designed integrin beta3 mutants stabilized in the high affinity conformation.
@en
Rationally designed integrin beta3 mutants stabilized in the high affinity conformation.
@nl
prefLabel
Rationally designed integrin beta3 mutants stabilized in the high affinity conformation.
@en
Rationally designed integrin beta3 mutants stabilized in the high affinity conformation.
@nl
P2093
P2860
P356
P1476
Rationally designed integrin beta3 mutants stabilized in the high affinity conformation.
@en
P2093
Bing-Hao Luo
John Karanicolas
Laura D Harmacek
Timothy A Springer
P2860
P304
P356
10.1074/JBC.M806312200
P407
P50
P577
2008-11-19T00:00:00Z