Relaxed replication of mtDNA: A model with implications for the expression of disease.
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Keeping mtDNA in shape between generationsRule-based cell systems model of aging using feedback loop motifs mediated by stress responsesMulti-system neurological disease is common in patients with OPA1 mutationsMitochondriaQuality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity?Gimap3 regulates tissue-specific mitochondrial DNA segregationDissecting the mechanisms underlying the accumulation of mitochondrial DNA deletions in human skeletal muscle.Stochastic drift in mitochondrial DNA point mutations: a novel perspective ex silicoControl of mitochondrial integrity in ageing and diseaseTransmission of mitochondrial DNA diseases and ways to prevent them.Multiple nuclear pseudogenes of mitochondrial cytochrome b in Ctenomys (Caviomorpha, rodentia) with either great similarity to or high divergence from the true mitochondrial sequence.Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals.OPA1 mutations cause cytochrome c oxidase deficiency due to loss of wild-type mtDNA molecules.Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles.Mitochondrial DNA mutations in human disease.Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism.Non-random mtDNA segregation patterns indicate a metastable heteroplasmic segregation unit in m.3243A>G cybrid cells.Wild-Type Mitochondrial DNA Copy Number in Urinary Cells as a Useful Marker for Diagnosing Severity of the Mitochondrial Diseases.Mathematical modeling of the role of mitochondrial fusion and fission in mitochondrial DNA maintenance.Evolution of the mitochondrial fusion-fission cycle and its role in agingAre mutagenic non D-loop direct repeat motifs in mitochondrial DNA under a negative selection pressure?Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutationsQuantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice.Mitochondrial DNA mutations in the hematopoietic system.Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA MutationsThe gastrointestinal stem cell.Normal levels of wild-type mitochondrial DNA maintain cytochrome c oxidase activity for two pathogenic mitochondrial DNA mutations but not for m.3243A-->G.Mitochondrial dysfunction in aging: Much progress but many unresolved questions.Mitochondrial DNA Heteroplasmy Associations With Neurosensory and Mobility Function in Elderly Adults.Universal heteroplasmy of human mitochondrial DNA.Mitochondrial DNA mutations in human colonic crypt stem cells.Selection against pathogenic mtDNA mutations in a stem cell population leads to the loss of the 3243A-->G mutation in bloodOne complex world of mitochondrial parkinsonismThe distribution of mitochondrial DNA heteroplasmy due to random genetic drift.Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations.Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction.Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging.Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans.Insight into mammalian mitochondrial DNA segregation.Simultaneous A8344G heteroplasmy and mitochondrial DNA copy number quantification in myoclonus epilepsy and ragged-red fibers (MERRF) syndrome by a multiplex molecular beacon based real-time fluorescence PCR.
P2860
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P2860
Relaxed replication of mtDNA: A model with implications for the expression of disease.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Relaxed replication of mtDNA: A model with implications for the expression of disease.
@en
Relaxed replication of mtDNA: A model with implications for the expression of disease.
@nl
type
label
Relaxed replication of mtDNA: A model with implications for the expression of disease.
@en
Relaxed replication of mtDNA: A model with implications for the expression of disease.
@nl
prefLabel
Relaxed replication of mtDNA: A model with implications for the expression of disease.
@en
Relaxed replication of mtDNA: A model with implications for the expression of disease.
@nl
P2860
P356
P1476
Relaxed replication of mtDNA: A model with implications for the expression of disease.
@en
P2093
D C Samuels
P2860
P304
P356
10.1086/302311
P407
P577
1999-04-01T00:00:00Z