Conformational Variations of Both Phosphodiesterase-5 and Inhibitors Provide the Structural Basis for the Physiological Effects of Vardenafil and Sildenafil

Conformational Variations of Both Phosphodiesterase-5 and Inhibitors Provide the Structural Basis for the Physiological Effects of Vardenafil and Sildenafil

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http://www.wikidata.org/entity/Q27648887
An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studiesKinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity † ‡Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and MutagenesisBiological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective InhibitorsPhosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.Advances in targeting cyclic nucleotide phosphodiesterasesStructural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric InhibitorIdentification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.Interactions between cyclic nucleotide phosphodiesterase 11 catalytic site and substrates or tadalafil and role of a critical Gln-869 hydrogen bond.Charting the interactome of PDE3A in human cells using an IBMX based chemical proteomics approach.Distinct allostery induced in the cyclic GMP-binding, cyclic GMP-specific phosphodiesterase (PDE5) by cyclic GMP, sildenafil, and metal ionsDirect allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.A Unique Sub-Pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS.Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development.
P2860

Conformational Variations of Both Phosphodiesterase-5 and Inhibitors Provide the Structural Basis for the Physiological Effects of Vardenafil and Sildenafil

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http://www.wikidata.org/entity/Q27648887
description
2008 nî lūn-bûn
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2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2008 թվականի հունվարին հրատարակված գիտական հոդված
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2008年の論文
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2008年論文
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2008年論文
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2008年論文
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2008年論文
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2008年論文
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2008年论文
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name
Conformational Variations of B ...... s of Vardenafil and Sildenafil
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Conformational Variations of B ...... s of Vardenafil and Sildenafil
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Conformational Variations of B ...... s of Vardenafil and Sildenafil
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Conformational Variations of B ...... s of Vardenafil and Sildenafil
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Conformational Variations of B ...... s of Vardenafil and Sildenafil
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Conformational Variations of B ...... s of Vardenafil and Sildenafil
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Conformational Variations of B ...... s of Vardenafil and Sildenafil
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Conformational Variations of B ...... s of Vardenafil and Sildenafil
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Conformational Variations of B ...... s of Vardenafil and Sildenafil
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Conformational Variations of B ...... s of Vardenafil and Sildenafil
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P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P932