about
Chemical dampening of Ly6C(hi) monocytes in the periphery produces anti-depressant effects in mice.An NQO1-initiated and p53-independent apoptotic pathway determines the anti-tumor effect of tanshinone IIA against non-small cell lung cancerThe pharmacokinetic-pharmacodynamic model of azithromycin for lipopolysaccharide-induced depressive-like behavior in miceUDP-glucuronosyltransferase 1A determinates intracellular accumulation and anti-cancer effect of β-lapachone in human colon cancer cellsPost acquisition data processing techniques for lipid analysis by quadrupole time-of-flight mass spectrometry.A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines.Epidermal growth factor receptor induced Erk phosphorylation in the suprachiasmatic nucleus.Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling.Epidermal growth factor receptor-induced circadian-time-dependent gene regulation in suprachiasmatic nucleus.Simultaneous determination of panax notoginsenoside R1, ginsenoside Rg1, Rd, Re and Rb1 in rat plasma by HPLC/ESI/MS: platform for the pharmacokinetic evaluation of total panax notoginsenoside, a typical kind of multiple constituent traditional ChinDetermination of sodium tanshinone IIA sulfonate in plasma by liquid chromatography-electrospray ionisation-tandem mass spectrometry.A fast carrier chromatin immunoprecipitation method applicable to microdissected tissue samples.Gas chromatography/time-of-flight mass spectrometry based metabonomic approach to differentiating hypertension- and age-related metabolic variation in spontaneously hypertensive rats.A sensitive and specific liquid chromatography/tandem mass spectrometry method for determination of echinacoside and its pharmacokinetic application in rats.Determination of 20(S)-ginsenoside Rh1 and its aglycone 20(S)-protopanaxatriol in rat plasma by sensitive LC-APCI-MS method and its application to pharmacokinetic study.Bioactive equivalence of combinatorial components identified in screening of an herbal medicine.PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis.Modeling the VPAC2-activated cAMP/PKA signaling pathway: from receptor to circadian clock gene inductionCytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance.Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way?A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines.Metabolic Pathway Extension Approach for Metabolomic Biomarker Identification.Characterization of isochlorogenic acid A metabolites in rats using high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.Combined effects of a high-fat diet and chronic valproic acid treatment on hepatic steatosis and hepatotoxicity in rats.Farnesoid X receptor activation promotes cell proliferation via PDK4-controlled metabolic reprogramming.Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis.Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis.UDP-glucuronosyltransferase 1A compromises intracellular accumulation and anti-cancer effect of tanshinone IIA in human colon cancer cellsDe-novo NAD+ synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells.Insights into drug discovery from natural medicines using reverse pharmacokinetics.Treat the brain and treat the periphery: toward a holistic approach to major depressive disorder.Comparison of bioactive components and pharmacological activities of ophiopogon japonicas extracts from different geographical origins.Metabolomics-Proteomics Combined Approach Identifies Differential Metabolism-Associated Molecular Events between Senescence and Apoptosis.Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium-Induced Colitis.Nontargeted diagnostic ion network analysis (NINA): A software to streamline the analytical workflow for untargeted characterization of natural medicines.Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line.Stepped collisional energy MS(All) : an analytical approach for optimal MS/MS acquisition of complex mixture with diverse physicochemical properties.Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats.Regioselective glucuronidation of tanshinone iia after quinone reduction: identification of human UDP-glucuronosyltransferases, species differences, and interaction potential.
P50
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P50
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հետազոտող
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Haiping Hao
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Haiping Hao
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55568897800
P31
P496
0000-0003-2522-7546