Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.
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Animal models of colorectal cancerRas-mediated deregulation of the circadian clock in cancer.Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations.Animal models of gastrointestinal and liver diseases. New mouse models for studying dietary prevention of colorectal cancerThe activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways.PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.Computational Identification of Key Regulators in Two Different Colorectal Cancer Cell Lines.Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation.A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations.Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer.The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair.KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer.The "cryptic" mechanism of action of glucagon-like peptide-2.RAS signalling in the colorectum in health and disease.Mechanisms of RAS/β-catenin interactions.Genomic instability and colon carcinogenesis: from the perspective of genes.Nuclear receptor-binding protein 1: a novel tumour suppressor and pseudokinase.Acute sensitivity of the oral mucosa to oncogenic K-ras.SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver.Activation of K-RAS by co-mutation of codons 19 and 20 is transformingWnt signaling, stem cells, and cancer of the gastrointestinal tract.Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.Lymph node-independent liver metastasis in a model of metastatic colorectal cancer.Deficiency of caveolin-1 in Apc(min/+) mice promotes colorectal tumorigenesis.Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras.Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomasInducible Intestine-Specific Expression of kras Triggers Intestinal Tumorigenesis In Transgenic Zebrafish
P2860
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P2860
Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.
description
2009 nî lūn-bûn
@nan
2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
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2009年學術文章
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name
Mutated K-ras(Asp12) promotes ...... etween K-ras and Wnt pathways.
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Mutated K-ras(Asp12) promotes ...... etween K-ras and Wnt pathways.
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Mutated K-ras(Asp12) promotes ...... etween K-ras and Wnt pathways.
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Mutated K-ras(Asp12) promotes ...... etween K-ras and Wnt pathways.
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Mutated K-ras(Asp12) promotes ...... etween K-ras and Wnt pathways.
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Mutated K-ras(Asp12) promotes ...... etween K-ras and Wnt pathways.
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P2093
P2860
P50
P1476
Mutated K-ras(Asp12) promotes ...... between K-ras and Wnt pathways
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P2093
Charles E Patek
David G Brooks
Douglas J Winton
Hongtao Ye
Mark J Arends
P2860
P304
P356
10.1111/J.1365-2613.2009.00667.X
P577
2009-10-01T00:00:00Z