Breaking the integrin hinge. A defined structural constraint regulates integrin signaling.
about
Crystal structure of the extracellular segment of integrin alpha Vbeta3Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domainsInvolvement of transmembrane domain interactions in signal transduction by alpha/beta integrinsThe structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signallingMigfilin, a molecular switch in regulation of integrin activationEvidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinasesSHARPIN is an endogenous inhibitor of β1-integrin activationStructure and function of the platelet integrin alphaIIbbeta3A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiationAffinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tailA specific interface between integrin transmembrane helices and affinity for ligandIntegrin bidirectional signaling: a molecular viewAction and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological SynapseSwing-out of the β3 hybrid domain is required for αIIbβ3 priming and normal cytoskeletal reorganization, but not adhesion to immobilized fibrinogenThe talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clusteringAnnular anionic lipids stabilize the integrin αIIbβ3 transmembrane complex.Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunitSolution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunitsEngineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studiesStructure of the Integrin IIb Transmembrane SegmentNMR solution conformations and interactions of integrin alphaLbeta2 cytoplasmic tailsThe structure of an integrin/talin complex reveals the basis of inside-out signal transduction.Structure of an integrin IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activationNMR analysis of the IIb 3 cytoplasmic interaction suggests a mechanism for integrin regulationIntegrin α1 Has a Long Helix, Extending from the Transmembrane Region to the Cytoplasmic Tail in Detergent MicellesBiology and structure of leukocyte β 2 integrins and their role in inflammationIdentification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domainsAncient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive stateIdentification of a novel interaction between integrin beta1 and 14-3-3betaIncreased filamin binding to beta-integrin cytoplasmic domains inhibits cell migrationMolecular basis of CIB binding to the integrin alpha IIb cytoplasmic domainPlatelet integrin alpha(IIb)beta(3): activation mechanismsICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activationThe LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs largeA Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast functionCell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinityProteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitmentCombinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis
P2860
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P2860
Breaking the integrin hinge. A defined structural constraint regulates integrin signaling.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
Breaking the integrin hinge. A ...... regulates integrin signaling.
@en
Breaking the integrin hinge. A ...... regulates integrin signaling.
@nl
type
label
Breaking the integrin hinge. A ...... regulates integrin signaling.
@en
Breaking the integrin hinge. A ...... regulates integrin signaling.
@nl
prefLabel
Breaking the integrin hinge. A ...... regulates integrin signaling.
@en
Breaking the integrin hinge. A ...... regulates integrin signaling.
@nl
P2093
P2860
P356
P1476
Breaking the integrin hinge. A ...... regulates integrin signaling.
@en
P2093
P2860
P304
P356
10.1074/JBC.271.12.6571
P407
P577
1996-03-01T00:00:00Z