The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop.
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The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activityCanonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinasesMolecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimerSerpin polymerization is prevented by a hydrogen bond network that is centered on his-334 and stabilized by glycerolCrystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug DesignVaspin inhibits kallikrein 7 by serpin mechanismHeparin binds lamprey angiotensinogen and promotes thrombin inhibition through a template mechanismAcyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitroMaspin inhibits cell migration in the absence of protease inhibitory activityCharacterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1)Identification and characterization of a novel rat ov-serpin family member, trespinA structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.The effects of reactive site location on the inhibitory properties of the serpin alpha(1)-antichymotrypsin.Serpin mechanism of hepatitis C virus nonstructural 3 (NS3) protease inhibition: induced fit as a mechanism for narrow specificity.Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization.Thrombin inhibition by serpins disrupts exosite IISerpins in rice: protein sequence analysis, phylogeny and gene expression during development.Rhipicephalus microplus serine protease inhibitor family: annotation, expression and functional characterisation assessment.AAV-mediated overexpression of neuroserpin in the hippocampus decreases PSD-95 expression but does not affect hippocampal-dependent learning and memory.Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18.Determining serpin conformational distributions with single molecule fluorescenceDesign and characterization of an APC-specific serpin for the treatment of hemophilia.alpha(1)-Proteinase inhibitor mutants with specificity for plasma kallikrein and C1s but not C1The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin.Exosite determinants of serpin specificity.Inhibition of the Membrane Attack Complex by Dengue Virus NS1 through Interaction with Vitronectin and Terminal Complement ProteinsAn antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.PEDF - A Noninhibitory Serpin with Neurotrophic Activity.Vaspin (serpinA12) in obesity, insulin resistance, and inflammation.Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance.Serpins in arthropod biology.Short-lived protease serpin complexes: partial disruption of the rat trypsin active site.A hydrophobic patch surrounding Trp154 in human neuroserpin controls the helix F dynamics with implications in inhibition and aggregation.Mutagenesis of the bovSERPINA3-3 demonstrates the requirement of aspartate-371 for intermolecular interaction and formation of dimers.Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations.Structural dynamics associated with intermediate formation in an archetypal conformational disease.Characterization of a site on PAI-1 that binds to vitronectin outside of the somatomedin B domain.Serpins show structural basis for oligomer toxicity and amyloid ubiquity.Specificity and reactive loop length requirements for crmA inhibition of serine proteases.Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway.
P2860
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P2860
The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
The serpin inhibitory mechanis ...... h of the reactive center loop.
@en
The serpin inhibitory mechanis ...... h of the reactive center loop.
@nl
type
label
The serpin inhibitory mechanis ...... h of the reactive center loop.
@en
The serpin inhibitory mechanis ...... h of the reactive center loop.
@nl
prefLabel
The serpin inhibitory mechanis ...... h of the reactive center loop.
@en
The serpin inhibitory mechanis ...... h of the reactive center loop.
@nl
P2093
P2860
P356
P1476
The serpin inhibitory mechanis ...... h of the reactive center loop.
@en
P2093
P2860
P304
27541-27547
P356
10.1074/JBC.M102594200
P407
P577
2001-04-26T00:00:00Z