Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins.
about
Synaptic vesicle trafficking and Parkinson's diseaseAlpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recyclingInteractions between fatty acids and alpha-synucleinA hIAPP-derived all-D-amino-acid inhibits hIAPP fibrillation efficiently at membrane surface by targeting α-helical oligomeric intermediatesThe synucleinsIs tau ready for admission to the prion club?Protein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitusAlpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosisAcyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolismAltered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathiesSolid-state ¹³C NMR reveals annealing of raft-like membranes containing cholesterol by the intrinsically disordered protein α-SynucleinDisease-toxicant interactions in Parkinson's disease neuropathologyOligomerization of Cu,Zn-Superoxide Dismutase (SOD1) by Docosahexaenoic Acid and Its Hydroperoxides In Vitro: Aggregation Dependence on Fatty Acid Unsaturation and Thiols.Biophysics of α-synuclein membrane interactions.Tyrosine Hydroxylase Binding to Phospholipid Membranes Prompts Its Amyloid Aggregation and Compromises Bilayer Integrity.Effect of 4-hydroxy-2-nonenal modification on alpha-synuclein aggregation.Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factorsDifferential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopyalpha-Synuclein abnormalities in mouse models of peroxisome biogenesis disorders.Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathiesLipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice.Metabolic Investigations of the Molecular Mechanisms Associated with Parkinson's DiseaseMonomeric α-synuclein binds Congo Red micelles in a disordered mannerStructure of membrane-bound alpha-synuclein studied by site-directed spin labelingPseudophosphorylation of tau protein directly modulates its aggregation kinetics.Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation.Alpha-synuclein function and dysfunction on cellular membranes.The many faces of α-synuclein: from structure and toxicity to therapeutic target.Α-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease.Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicityLipid peroxidation is essential for α-synuclein-induced cell death.Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans.Structural intermediates during α-synuclein fibrillogenesis on phospholipid vesicles.Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cellsExosomal cell-to-cell transmission of alpha synuclein oligomers.Helix periodicity, topology, and dynamics of membrane-associated alpha-synuclein.Calcium(II) selectively induces alpha-synuclein annular oligomers via interaction with the C-terminal domainα-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles.The interplay between lipids and dopamine on α-synuclein oligomerization and membrane binding.Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy
P2860
Q24302024-A26AB2E0-487D-4BB4-B973-3DBA8558FA6CQ24311523-1CBB09CF-E464-48A2-8A3E-8BF7EA14EA87Q24336967-25064031-6135-4CA3-B039-20FDAD6592AFQ24338147-6080A4BF-C98F-4175-80AA-C5177D9AC559Q24551013-F20154E6-CF1E-4039-B6BB-966AB2E6FEA2Q24630925-74992256-78D3-4622-96BF-E17FD35D6B32Q28397425-EB6B5415-F497-42B1-803A-F2FD5C040A0CQ28580852-D924CE60-6F82-4CDD-87A6-ABF9A4B1906AQ28586519-E0453363-AC8B-4088-9A6B-86FBA867DDD8Q28591852-A332F5C6-E90A-4609-BBE3-4E4E43189F45Q28817941-D263F889-8AD4-437F-A137-B5BC331AEB9BQ29248297-82A2A655-89A1-43D7-8C4C-A64FE09C19D5Q30374274-0B3EDD47-58C6-4F74-AF40-610B1341A60BQ30405705-574665D5-AB1E-4E7D-9E8D-CA5C1876975BQ30832756-7C12B5B2-02CD-48E5-BE60-C68561C8536DQ33267617-46DF0227-B5A2-445D-B55D-564F959C8BB2Q33371063-3F8210B0-FF03-4547-B9B3-90E7B331B0E5Q33627226-7C407FE2-A55B-4360-920C-8BA54111E09AQ33643679-1CBE2AEB-5D5E-4C00-BC9E-1AA41A677AA2Q33715640-138E2FB8-815C-4DA9-895E-A49C74E810F6Q33724346-4F7C9312-7B79-41EE-B751-F86EE9CA9496Q33844949-09B6920A-2E2E-4495-A70A-F53AB0D81C03Q34126935-D4E2CFE6-6A62-432A-B5C7-C431D826C848Q34375103-3C64DAF7-1A33-45DF-BA58-CE4238DE1565Q34478697-512F7CFA-59EB-42C3-A594-B6476FF57A6DQ34648491-89CD54C6-DF0D-457A-BFAD-BB0BE4F91094Q34774324-D4C69D6E-E4D3-44AE-A571-626507B97D38Q34972009-D763E5CC-14FA-461F-8C1A-3A979B6526ECQ35658620-B7C9942F-BC29-4E93-B292-0FFA951781A6Q35691076-BEB3E531-676E-4C9A-9660-145355595C6AQ35752895-3AD9FAD3-C8E2-4B19-8FFA-BFCB3493B854Q35802054-FE0112A0-02CD-43A6-B62A-EDFDD5FDF012Q35902646-EBD8C5D7-1C76-4F7D-BD76-7D3D00DF17A6Q36202906-F872127C-779A-4B9B-ACB8-74819A8DFB01Q36353854-E3C27ED9-6F65-4BC5-B9CD-3D82CF85A9CFQ36476930-C5D701D9-09FD-47F5-9DBD-B971C0F63A07Q36527246-698C69EB-033D-4C35-82C7-6397C07C2BD6Q36929059-1489BA85-6120-4EE7-AB9E-D65060E1B930Q37246310-0D8B2FA2-4F85-4801-B3AE-8492D2559F75Q37258811-0B586C68-1069-40F8-84B6-87E90AB13504
P2860
Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Exposure to long chain polyuns ...... multimerization of synucleins.
@en
Exposure to long chain polyuns ...... multimerization of synucleins.
@nl
type
label
Exposure to long chain polyuns ...... multimerization of synucleins.
@en
Exposure to long chain polyuns ...... multimerization of synucleins.
@nl
prefLabel
Exposure to long chain polyuns ...... multimerization of synucleins.
@en
Exposure to long chain polyuns ...... multimerization of synucleins.
@nl
P2860
P356
P1476
Exposure to long chain polyuns ...... multimerization of synucleins
@en
P2093
P2860
P304
41958-41962
P356
10.1074/JBC.M105022200
P407
P577
2001-09-11T00:00:00Z