The human serotonin 5-HT4 receptor regulates secretion of non-amyloidogenic precursor protein.
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5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j miceG Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRsRegulation of amyloid precursor protein processing by serotonin signalingInterleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y(2) receptorTreatment of dementia with neurotransmission modulation.The purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor proteinEffects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice.An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice.Alzheimer's disease and age-related memory decline (preclinical)Characterization of human 5-HT4(d) receptor desensitization in CHO cells.New insights into the human 5-HT4 receptor binding site: exploration of a hydrophobic pocket.A pharmacological analysis of an associative learning task: 5-HT(1) to 5-HT(7) receptor subtypes function on a pavlovian/instrumental autoshaped memory.Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivo.Epigenetic dysregulation of brainstem nuclei in the pathogenesis of Alzheimer's disease: looking in the correct place at the right time?Role of serotonin in Alzheimer's disease: a new therapeutic target?The role of serotonin in memory: interactions with neurotransmitters and downstream signaling.Serotonergic therapies for cognitive symptoms in Alzheimer's disease: rationale and current status.Modulating 5-HT4 and 5-HT6 receptors in Alzheimer's disease treatment.Current pharmacotherapy and putative disease-modifying therapy for Alzheimer's disease.Cilostazol suppresses β-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor-β.Crosstalk between angiotensin and the nonamyloidogenic pathway of Alzheimer's amyloid precursor protein.Role of cAMP/PKA pathway and T-type calcium channels in the mechanism of action of serotonin in human adrenocortical cells.Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.Functional studies of the 5'-untranslated region of human 5-HT4 receptor mRNA.5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha.Nonyloxytryptamine mimics polysialic acid and modulates neuronal and glial functions in cell culture.In-vivo rat striatal 5-HT4 receptor occupancy using non-radiolabelled SB207145.Epac signaling pathway involves STEF, a guanine nucleotide exchange factor for Rac, to regulate APP processing.High tryptophan diet reduces CA1 intraneuronal β-amyloid in the triple transgenic mouse model of Alzheimer's disease.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Sex differences in chronic stress responses and Alzheimer's disease.
P2860
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P2860
The human serotonin 5-HT4 receptor regulates secretion of non-amyloidogenic precursor protein.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
The human serotonin 5-HT4 rece ...... yloidogenic precursor protein.
@en
The human serotonin 5-HT4 rece ...... yloidogenic precursor protein.
@nl
type
label
The human serotonin 5-HT4 rece ...... yloidogenic precursor protein.
@en
The human serotonin 5-HT4 rece ...... yloidogenic precursor protein.
@nl
prefLabel
The human serotonin 5-HT4 rece ...... yloidogenic precursor protein.
@en
The human serotonin 5-HT4 rece ...... yloidogenic precursor protein.
@nl
P2093
P2860
P356
P1476
The human serotonin 5-HT4 rece ...... myloidogenic precursor protein
@en
P2093
A M Gardier
F Lezoualc'h
J L Zugaza
S J Robert
P2860
P304
44881-44888
P356
10.1074/JBC.M109008200
P407
P577
2001-10-02T00:00:00Z