Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha. - Wikidata - awgldk - TriplyDB

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha.

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha.

http://www.wikidata.org/entity/Q44486482

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Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes 5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons Molecular mechanisms in uterine epithelium during trophoblast binding: the role of small GTPase RhoA in human uterine Ishikawa cells.Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK Cell physiology of cAMP sensor Epac.Regulation of amyloid precursor protein processing by serotonin signaling Downregulation of Rap1GAP contributes to Ras transformation Dissecting the mechanism of Epac activation via hydrogen-deuterium exchange FT-IR and structural modeling.Breaking down to build up: Neuroligin's C-terminal domain strengthens the synapse.Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac.Epac mediates PACAP-dependent long-term depression in the hippocampus.Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway.Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1 Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster.A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac.PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis.Anchoring junctions as drug targets: role in contraceptive development.Enforced hematopoietic cell E- and L-selectin ligand (HCELL) expression primes transendothelial migration of human mesenchymal stem cells.Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment.Purification and identification of G protein-coupled receptor protein complexes under native conditions.Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus Epac and PKA: a tale of two intracellular cAMP receptors.A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation Hypoxia/reoxygenation-experienced cancer cell migration and metastasis are regulated by Rap1- and Rac1-GTPase activation via the expression of thymosin beta-4.Genetic variation in G-protein-coupled receptors--consequences for G-protein-coupled receptors as drug targets.Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors The neurotrophic effects of PACAP in PC12 cells: control by multiple transduction pathways.Big roles for small GTPases in the control of directed cell movement.Novel modulators of amyloid-beta precursor protein processing.Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?Establishment and maintenance of cell polarity during leukocyte chemotaxis Tumor cell migration and invasion are enhanced by depletion of Rap1 GTPase-activating protein (Rap1GAP)Cdc42 is an antihypertrophic molecular switch in the mouse heart.Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.Systematic protein-protein interaction mapping for clinically relevant human GPCRs

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P2860

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha.

http://www.wikidata.org/entity/Q44486482

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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name

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha.

@en

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha.

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type

label

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha.

@en

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha.

@nl

prefLabel

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha.

@en

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha.

@nl

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Nature Cell Biology

P1476

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha.

@en

P2093

Frank Lezoualc'h

http://www.w3.org/2001/XMLSchema#string

Jacques Bertoglio

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José L Zugaza

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Marjorie Maillet

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Mathias Cacquevel

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Monique Gastineau

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Sylvain J Robert

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P2860

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI

Structure and regulation of the cAMP-binding domains of Epac2

Protein kinase A-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells: role of Epac I

Signaling to Rho GTPases.

The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound.

Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation.

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633-639

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10.1038/NCB1007

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7

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5

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Rodolphe Fischmeister

Rodolphe Fischmeister

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2003-07-01T00:00:00Z

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10696404

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12819788

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