FRA3B and other common fragile sites: the weakest links.
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The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activityFhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cellsChromosomal instability at common fragile sites in Seckel syndromeStrong association of de novo copy number mutations with autismFunctional association between Wwox tumor suppressor protein and p73, a p53 homologA sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genomeFrequent downregulation and loss of WWOX gene expression in human hepatocellular carcinomaThe FHIT gene product: tumor suppressor and genome "caretaker"WWOX, the common chromosomal fragile site, FRA16D, cancer geneInitiation of genome instability and preneoplastic processes through loss of Fhit expressionThe histidine triad protein Hint is not required for murine development or Cdk7 functionPooled analysis of loss of heterozygosity in breast cancer: a genome scan provides comparative evidence for multiple tumor suppressors and identifies novel candidate regions.A novel approach to simultaneously scan genes at fragile sites45S rDNA regions are chromosome fragile sites expressed as gaps in vitro on metaphase chromosomes of root-tip meristematic cells in Lolium spp.Replicative Stress and the FHIT Gene: Roles in Tumor Suppression, Genome Stability and Prevention of Carcinogenesis.PTEN C-terminal deletion causes genomic instability and tumor development.Large-scale analysis of adeno-associated virus vector integration sites in normal human cells.A survey of homozygous deletions in human cancer genomes.Association between decreased WWOX protein expression and thyroid cancer developmentLow levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours.Integrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer.DNA instability at chromosomal fragile sites in cancerPlant 45S rDNA clusters are fragile sites and their instability is associated with epigenetic alterationsFragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenicWWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response.Common fragile site tumor suppressor genes and corresponding mouse models of cancer.An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiaeSMAD5 gene expression, rearrangements, copy number, and amplification at fragile site FRA5C in human hepatocellular carcinomaTwo Distinct Categories of Focal Deletions in Cancer Genomes.Comparative genomic mapping of the bovine Fragile Histidine Triad (FHIT) tumour suppressor gene: characterization of a 2 Mb BAC contig covering the locus, complete annotation of the gene, analysis of cDNA and of physiological expression profiles.Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instabilityFHIT gene expression is repressed by mitogenic signaling through the PI3K/AKT/FOXO pathway.Two breakpoint clusters at fragile site FRA3B form phased nucleosomes.Alteration of the fragile histidine triad gene early in carcinogenesis: an update.Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins.The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.Multicolour-banding fluorescence in situ hybridisation (mbanding-FISH) to identify recurrent chromosomal alterations in breast tumour cell lines.Cancer and the FRA3B/FHIT fragile locus: it's a HITWWOX in biological control and tumorigenesis.Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions
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P2860
FRA3B and other common fragile sites: the weakest links.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
FRA3B and other common fragile sites: the weakest links.
@en
FRA3B and other common fragile sites: the weakest links.
@nl
type
label
FRA3B and other common fragile sites: the weakest links.
@en
FRA3B and other common fragile sites: the weakest links.
@nl
prefLabel
FRA3B and other common fragile sites: the weakest links.
@en
FRA3B and other common fragile sites: the weakest links.
@nl
P2860
P356
P1476
FRA3B and other common fragile sites: the weakest links.
@en
P2093
P2860
P2888
P304
P356
10.1038/35106058
P407
P577
2001-12-01T00:00:00Z