Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy.
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Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmiasTransgenic analysis of the role of FKBP12.6 in cardiac function and intracellular calcium releaseKinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparksIn situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6Androgen receptor (AR) in cardiovascular diseasesFK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?Effects of biological sex on the pathophysiology of the heartDysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6Localization of the 12.6-kDa FK506-binding protein (FKBP12.6) binding site to the NH2-terminal domain of the cardiac Ca2+ release channel (ryanodine receptor)Interaction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domainDistinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cellsDissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytesEstrogen inhibits cardiomyocyte hypertrophy in vitro. Antagonism of calcineurin-related hypertrophy through induction of MCIP1RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscleInactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice.FKBP12.6-knockout mice display hyperinsulinemia and resistance to high-fat diet-induced hyperglycemiaFKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cellsTGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytesMechanistic Pathways of Sex Differences in Cardiovascular Disease.Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice.Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.FKBP12.6 overexpression decreases Ca2+ spark amplitude but enhances [Ca2+]i transient in rat cardiac myocytes.Modification of sarcoplasmic reticulum (SR) Ca2+ release by FK506 induces defective excitation-contraction coupling only when SR Ca2+ recycling is disturbed.ERβ selective agonist inhibits angiotensin-induced cardiovascular pathology in female miceInfluence of sex hormones and phytoestrogens on heart disease in men and womenROS-dependent signaling mechanisms for hypoxic Ca(2+) responses in pulmonary artery myocytes.Pin1 deficiency causes endothelial dysfunction and hypertension.Mechanisms of sudden cardiac death.A simple and efficient route to the FKBP-binding domain from rapamycinFKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.Estrogen receptor-beta prevents cardiac fibrosis.17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overloadExcitation-contraction coupling gain and cooperativity of the cardiac ryanodine receptor: a modeling approach.Three-dimensional visualization of FKBP12.6 binding to an open conformation of cardiac ryanodine receptorThe ryanodine receptor in cardiac physiology and disease.Functional role of Calstabin2 in age-related cardiac alterations.FK506 binding protein 12 deficiency in endothelial and hematopoietic cells decreases regulatory T cells and causes hypertension.Regulation of Ryanodine Receptor Ion Channels Through Posttranslational Modifications.Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)).The therapeutic potential of new insights into myocardial excitation-contraction coupling.
P2860
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P2860
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy.
@en
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy.
@nl
type
label
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy.
@en
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy.
@nl
prefLabel
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy.
@en
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy.
@nl
P2093
P356
P1433
P1476
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy.
@en
P2093
Dong-Sheng Cheng
Guang-Ju Ji
Hong-Bo Xin
Julio A Copello
Ke-Yu Deng
Loice H Jeyakumar
Mei Lin Collier
Michael I Kotlikoff
Sidney Fleischer
Tadashi Inagami
P2888
P304
P356
10.1038/416334A
P407
P577
2002-03-01T00:00:00Z
P6179
1044156002