A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis.
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Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic interventionConcordant modulation of cysteinyl leukotriene receptor expression by IL-4 and IFN-gamma on peripheral immune cells.Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice.A prostacyclin analogue, iloprost, protects from bleomycin-induced pulmonary fibrosis in miceClinical relevance of plasma prostaglandin F2α metabolite concentrations in patients with idiopathic pulmonary fibrosis.Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substratesPivotal role of cathepsin K in lung fibrosis.Integrating mechanisms of pulmonary fibrosisHost cytosolic phospholipase A₂α contributes to group B Streptococcus penetration of the blood-brain barrier.A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophagesCytosolic phospholipase A2 modulates TLR2 signaling in synoviocytesDisorders of lung matrix remodeling.Cytosolic phospholipase A₂: physiological function and role in disease.Group V secretory PLA2 regulates TLR2-dependent eicosanoid generation in mouse mast cells through amplification of ERK and cPLA2alpha activation.Cytosolic phospholipase A2 contributes to innate immune defense against Candida albicans lung infectionCytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway.Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritisInhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis.Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidaseCysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function.Regulation of cytosolic phospholipase A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages.Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis.Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinaseRegulation of Wnt/beta-catenin pathway by cPLA2alpha and PPARdeltaStructure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors.Low molecular weight hyaluronan activates cytosolic phospholipase A2α and eicosanoid production in monocytes and macrophages.Inflammatory signalings involved in airway and pulmonary diseases.Effectiveness of the ICare rebound tonometer in patients with overestimated intraocular pressure due to tight orbit syndrome.Activation of cytosolic phospholipase A2alpha through nitric oxide-induced S-nitrosylation. Involvement of inducible nitric-oxide synthase and cyclooxygenase-2.Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury.Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages.Cysteinyl leukotrienes as novel host factors facilitating Cryptococcus neoformans penetration into the brain.Inhibition of secretory phospholipase A2 activity attenuates lipopolysaccharide-induced acute lung injury in a mouse model.Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis.Cytosolic phospholipase A2alpha regulates induction of brain cyclooxygenase-2 in a mouse model of inflammation.CD1a presentation of endogenous antigens by group 2 innate lymphoid cells.Bone marrow-derived cPLA2α contributes to renal fibrosis progression.New therapeutic key for cystic fibrosis: a role for lipoxins.Involvement of platelet-activating factor and LIS1 in neuronal migration.Calcitonin gene-related peptide mediates acid-induced lung injury in mice.
P2860
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P2860
A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
A pivotal role of cytosolic phospholipase A
@nl
A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis.
@en
type
label
A pivotal role of cytosolic phospholipase A
@nl
A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis.
@en
prefLabel
A pivotal role of cytosolic phospholipase A
@nl
A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis.
@en
P2093
P356
P1433
P1476
A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis.
@en
P2093
Eijiro Ohga
Hiroshi Yamamoto
Naonori Uozumi
Satoshi Ishii
Takahide Nagase
Takao Shimizu
Yasuyoshi Ouchi
Yoshihiro Kita
P2888
P304
P356
10.1038/NM0502-480
P407
P577
2002-05-01T00:00:00Z
P6179
1052946487