Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
about
VHL type 2B mutations retain VBC complex form and functionTranscriptional adaptations following exercise in thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophyMammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulationA yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor proteinIdentification of novel VHL target genes and relationship to hypoxic response pathwaysHIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activityThe forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanismThe von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repressionNovel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomasSomatic HIF2A gain-of-function mutations in paraganglioma with polycythemiavon Hippel-Lindau disease: a clinical and scientific reviewState of the science: an update on renal cell carcinomaIdentification of Ror2 as a hypoxia-inducible factor target in von Hippel-Lindau-associated renal cell carcinomaThe VHL tumor suppressor: master regulator of HIFHypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growthA common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1alpha (HIF-1alpha) does not impair Pro-564 hydroxylationGenetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegansA HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomasGene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancersSequential pathogenesis of metastatic VHL mutant clear cell renal cell carcinoma: putting it together with a translational perspectiveNovel targeting of phosphatidylinositol 3-kinase and mammalian target of rapamycin in renal cell carcinomaRINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisHIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progressionRenal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cystsAllosteric inhibition of hypoxia inducible factor-2 with small moleculesHypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer.Molecular Connections between Cancer Cell Metabolism and the Tumor MicroenvironmentThe roles of chromatin-remodelers and epigenetic modifiers in kidney cancerThe myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteinsHypoxia-inducible factors in the kidneyReduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasionELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinomaMiR-338-3p inhibits hepatocarcinoma cells and sensitizes these cells to sorafenib by targeting hypoxia-induced factor 1αInactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice.Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulationBreaking through a plateau in renal cell carcinoma therapeutics: development and incorporation of biomarkersHIF1α and HIF2α independently activate SRC to promote melanoma metastases
P2860
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P2860
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
@en
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
@nl
type
label
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
@en
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
@nl
prefLabel
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
@en
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
@nl
P2093
P1433
P1476
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
@en
P2093
Eijiro Nakamura
Keiichi Kondo
Mirna Lechpammer
P304
P356
10.1016/S1535-6108(02)00043-0
P577
2002-04-01T00:00:00Z