Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis.
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Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent isletsRole for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretionElimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shuntMalic enzyme is present in mouse islets and modulates insulin secretionImmunochemical identification of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate and pyruvate dehydrogenase complexes partially explains the cellular toxicity of coenzyme Q0.Clusters of conserved beta cell marker genes for assessment of beta cell phenotype.ß-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretionImmunocytochemical localization of glucose 6-phosphatase and cytosolic phosphoenolpyruvate carboxykinase in gluconeogenic tissues reveals unsuspected metabolic zonation.Identification of ATP synthase as a lipid peroxide protein adduct in pancreatic islets from humans with and without type 2 diabetes mellitus.Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion.Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion.NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells.Metabolic substrates exhibit differential effects on functional parameters of mouse sperm capacitationModeling the neurovascular niche: murine strain differences mimic the range of responses to chronic hypoxia in the premature newborn.Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line.Functional implications of long non-coding RNAs in the pancreatic islets of Langerhans.Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice.The Pancreatic β-Cell: A Bioenergetic Perspective.Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion.Functional differences between aggregated and dispersed insulin-producing cells.Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cellsImpaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase.A kinetic core model of the glucose-stimulated insulin secretion network of pancreatic beta cells.Chronic exposure to beta-hydroxybutyrate inhibits glucose-induced insulin release from pancreatic islets by decreasing NADH contents.Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.Mitochondrial regulation of insulin production in rat pancreatic islets.Co-culture of primary neural progenitor and endothelial cells in a macroporous gel promotes stable vascular networks in vivo.A mathematical model of the mitochondrial NADH shuttles and anaplerosis in the pancreatic beta-cell.Choline supplementation improves the lipid metabolism of intrauterine-growth-restricted pigs.
P2860
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P2860
Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis.
description
2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Differences between mouse and ...... malic enzyme, and anaplerosis.
@en
Differences between mouse and ...... malic enzyme, and anaplerosis.
@nl
type
label
Differences between mouse and ...... malic enzyme, and anaplerosis.
@en
Differences between mouse and ...... malic enzyme, and anaplerosis.
@nl
prefLabel
Differences between mouse and ...... malic enzyme, and anaplerosis.
@en
Differences between mouse and ...... malic enzyme, and anaplerosis.
@nl
P2860
P1476
Differences between mouse and ...... malic enzyme, and anaplerosis.
@en
P2093
Michael J MacDonald
P2860
P304
P356
10.1152/AJPENDO.00041.2002
P577
2002-08-01T00:00:00Z