Weak strand displacement activity enables human DNA polymerase beta to expand CAG/CTG triplet repeats at strand breaks.
about
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta.The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity.DNA pol λ's extraordinary ability to stabilize misaligned DNA.The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision repair outcome at CAG/CTG repeatsRate-determining Step of Flap Endonuclease 1 (FEN1) Reflects a Kinetic Bias against Long Flaps and Trinucleotide Repeat Sequences.Mutation of DNA polymerase beta in esophageal carcinoma of different regionsOligodeoxynucleotide binding to (CTG) · (CAG) microsatellite repeats inhibits replication fork stalling, hairpin formation, and genome instability.Mitochondrial DNA damage and repair in neurodegenerative disorders.Features of trinucleotide repeat instability in vivo.OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cellsCoordination between polymerase beta and FEN1 can modulate CAG repeat expansion.Abnormal base excision repair at trinucleotide repeats associated with diseases: a tissue-selective mechanism.Break-induced replication links microsatellite expansion to complex genome rearrangements.Single-stranded DNA-binding protein in vitro eliminates the orientation-dependent impediment to polymerase passage on CAG/CTG repeats.Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility.DNA expansions generated by human Polμ on iterative sequences.DNA repair and DNA triplet repeat expansion: the impact of abasic lesions on triplet repeat DNA energetics.The myotonic dystrophy type 1 triplet repeat sequence induces gross deletions and inversions.Hairpin formation in Friedreich's ataxia triplet repeat expansion.
P2860
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P2860
Weak strand displacement activity enables human DNA polymerase beta to expand CAG/CTG triplet repeats at strand breaks.
description
2002 nî lūn-bûn
@nan
2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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name
Weak strand displacement activ ...... plet repeats at strand breaks.
@en
Weak strand displacement activ ...... plet repeats at strand breaks.
@nl
type
label
Weak strand displacement activ ...... plet repeats at strand breaks.
@en
Weak strand displacement activ ...... plet repeats at strand breaks.
@nl
prefLabel
Weak strand displacement activ ...... plet repeats at strand breaks.
@en
Weak strand displacement activ ...... plet repeats at strand breaks.
@nl
P2093
P2860
P356
P1476
Weak strand displacement activ ...... plet repeats at strand breaks.
@en
P2093
John Petruska
Michael J Hartenstine
Myron F Goodman
P2860
P304
41379-41389
P356
10.1074/JBC.M207013200
P407
P577
2002-08-23T00:00:00Z