p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I.
about
Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused reviewTNNI3K is a novel mediator of myofilament function and phosphorylates cardiac troponin ISmall G proteins in the cardiovascular system: physiological and pathological aspectsA preferred AMPK phosphorylation site adjacent to the inhibitory loop of cardiac and skeletal troponin IMultiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human HeartTNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships.Reduced force production during low blood flow to the heart correlates with altered troponin I phosphorylationTransmural heterogeneity of cellular level power output is reduced in human heart failure.Increased phosphorylation of tropomyosin, troponin I, and myosin light chain-2 after stretch in rabbit ventricular myocardium under physiological conditions.Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.Structural and kinetic effects of PAK3 phosphorylation mimic of cTnI(S151E) on the cTnC-cTnI interaction in the cardiac thin filamentTop-down mass spectrometry of cardiac myofilament proteins in health and disease.Redox signaling and cardiac sarcomeresPAK1 as a therapeutic target.Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2AAccurate quantification of cardiovascular biomarkers in serum using Protein Standard Absolute Quantification (PSAQ™) and selected reaction monitoringIn vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated.AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function.Impact of hydroxyl radical-induced injury on calcium handling and myofilament sensitivity in isolated myocardium.Heart failure, myocardial stunning, and troponin: a key regulator of the cardiac myofilament.Cardiomyocyte-specific overexpression of an active form of Rac predisposes the heart to increased myocardial stunning and ischemia-reperfusion injuryp21-Activated kinase-1 and its role in integrated regulation of cardiac contractility.Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytesO-linked GlcNAc modification of cardiac myofilament proteins: a novel regulator of myocardial contractile function.The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation.Protein kinase A-dependent modulation of Ca2+ sensitivity in cardiac and fast skeletal muscles after reconstitution with cardiac troponin.Pak protein kinases and their role in cancer.Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β.PR65A phosphorylation regulates PP2A complex signaling.Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration.β-Arrestin mediates the Frank-Starling mechanism of cardiac contractilityNew potential uses for cardiac troponins.PAK signaling in cancer.Posttranslational modifications of desmin and their implication in biological processes and pathologies.Pathomechanisms in heart failure: the contractile connection.Tri-modal regulation of cardiac muscle relaxation; intracellular calcium decline, thin filament deactivation, and cross-bridge cycling kinetics.Using baculovirus/insect cell expressed recombinant actin to study the molecular pathogenesis of HCM caused by actin mutation A331PBack to the future: new techniques show that forgotten phosphorylation sites are present in contractile proteins of the heart whilst intensively studied sites appear to be absent.Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry.The art of the deal in myofilament modulation of function.
P2860
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P2860
p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
p21-activated kinase increases ...... phosphorylation of troponin I.
@en
p21-activated kinase increases ...... phosphorylation of troponin I.
@nl
type
label
p21-activated kinase increases ...... phosphorylation of troponin I.
@en
p21-activated kinase increases ...... phosphorylation of troponin I.
@nl
prefLabel
p21-activated kinase increases ...... phosphorylation of troponin I.
@en
p21-activated kinase increases ...... phosphorylation of troponin I.
@nl
P2093
P1433
P1476
p21-activated kinase increases ...... phosphorylation of troponin I.
@en
P2093
D Brian Foster
Irina Neverova
Jennifer E Van Eyk
Nina Buscemi
P304
P356
10.1161/01.RES.0000035246.27856.53
P577
2002-09-01T00:00:00Z