Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.
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Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell functionDecreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell functionPhysiologic characterization of type 2 diabetes-related lociNovel phenotypes of prediabetes?Non-alcoholic fatty liver disease and type 2 diabetes mellitus: the liver disease of our age?Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and diseaseEvaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell functionLipotoxicity disrupts incretin-regulated human β cell connectivityVariance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population.Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps.Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function.Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: Incretin actions beyond the pancreas.TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndromeGene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes.Interactions between genetic factors that predict diabetes and dietary factors that ultimately impact on risk of diabetes.Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humansClinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146.The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest.The sum of many parts: potential mechanisms for improvement in glucose homeostasis after bariatric surgeryIs the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function?JNK3 is required for the cytoprotective effect of exendin 4Transcription factor 7-like 2 (TCF7L2) polymorphism and hyperglycemia in an adult Italian population-based cohort.A model of GLP-1 action on insulin secretion in nondiabetic subjects.Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin.Genetics of type 2 diabetes in European populations.Role of BMI in the Association of the TCF7L2 rs7903146 Variant with Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study.COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathwaysExpression of the diabetes-associated gene TCF7L2 in adult mouse brainPotential role of TCF7L2 gene variants on cardiac sympathetic/parasympathetic activityCarriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2.Patient profiling in diabetes and role of canagliflozin.The search for genetic risk factors of type 2 diabetes mellitus.Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146Association of TCF7L2 allelic variations with gastric function, satiation, and GLP-1 levels.Polymorphisms of GLP-1 receptor gene and response to GLP-1 analogue in patients with poorly controlled type 2 diabetes.Polymorphism of Transcription Factor-7-Like 2 (TCF7L2) Gene and New-Onset Diabetes after Liver Transplantation.The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis.β-Cell Sensitivity to GLP-1 in Healthy Humans Is Variable and Proportional to Insulin Sensitivity.
P2860
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P2860
Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Impaired glucagon-like peptide ...... 2 (TCF7L2) gene polymorphisms.
@ast
Impaired glucagon-like peptide ...... 2 (TCF7L2) gene polymorphisms.
@en
type
label
Impaired glucagon-like peptide ...... 2 (TCF7L2) gene polymorphisms.
@ast
Impaired glucagon-like peptide ...... 2 (TCF7L2) gene polymorphisms.
@en
prefLabel
Impaired glucagon-like peptide ...... 2 (TCF7L2) gene polymorphisms.
@ast
Impaired glucagon-like peptide ...... 2 (TCF7L2) gene polymorphisms.
@en
P2093
P2860
P50
P1433
P1476
Impaired glucagon-like peptide ...... 2 (TCF7L2) gene polymorphisms
@en
P2093
A Fritsche
B Gallwitz
F Machicao
H U Häring
J M Dekker
O Tschritter
S A Schäfer
T W van Haeften
P2860
P2888
P304
P356
10.1007/S00125-007-0753-6
P577
2007-07-28T00:00:00Z