Synthesis and reactions of the highly mutagenic 7,8-diol 9,10-epoxides of the carcinogen benzo[a]pyrene.
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Highly diastereoselective synthesis of nucleoside adducts from the carcinogenic benzo[a]pyrene diol epoxide and a computational analysis.Crystal and molecular structure of a benzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct: absolute configuration and conformationRole of diaxial versus diequatorial hydroxyl groups in the tumorigenic activity of a benzo[a]pyrene bay-region diol epoxide.Adaptive upregulation of DNA repair genes following benzo(a)pyrene diol epoxide protects against cell death at the expense of mutations.Identification of the major adducts formed by reaction of benzo(a)pyrene diol epoxide with DNA in vitroComparative metabolism of benzo[a]pyrene by human keratinocytes infected with high-risk human papillomavirus types 16 and 18 as episomal or integrated genomes.Modular, Metal-Catalyzed Cycloisomerization Approach to Angularly Fused Polycyclic Aromatic Hydrocarbons and Their Oxidized Derivatives.Mechanism of the inhibition of mutagenicity of a benzo[a]pyrene 7,8-diol 9,10-epoxide by riboflavin 5'-phosphateInhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: exceptional activity of ellagic acidCarcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism.Epoxidation of (+/-)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene during (bi)sulfite autoxidation: activation of a procarcinogen by a cocarcinogen.Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.Relationships of quantum mechanical calculations, relative mutagenicity of benzo[a]anthracene diol epoxides, and "bay region" concept of aromatic hydrocarbon carcinogenicity.Chemical strategies for the inactivation of bay-region diol epoxides, ultimate carcinogens derived from polycyclic aromatic hydrocarbons.Polycyclic aromatic hydrocarbon diol epoxides increase cytosolic Ca(2+) of airway epithelial cells.Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage.Xenobiotic metabolism by prostaglandin endoperoxide synthetase.Palladium-catalyzed synthesis of nucleoside adducts from bay- and fjord-region diol epoxides.The nucleotide excision repair protein XPC is essential for bulky DNA adducts to promote interleukin-6 expression via the activation of p38-SAPK.Multidrug resistance-associated proteins are involved in the transport of the glutathione conjugates of the ultimate carcinogen of benzo[a]pyrene in human Caco-2 cells.Toxic agents resulting from the oxidative metabolism of steroid hormones and drugs.
P2860
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P2860
Synthesis and reactions of the highly mutagenic 7,8-diol 9,10-epoxides of the carcinogen benzo[a]pyrene.
description
1977 nî lūn-bûn
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1977年の論文
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1977年学术文章
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1977年学术文章
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1977年学术文章
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1977年学术文章
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1977年學術文章
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1977年學術文章
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name
Synthesis and reactions of the ...... the carcinogen benzo[a]pyrene.
@en
Synthesis and reactions of the ...... the carcinogen benzo[a]pyrene.
@nl
type
label
Synthesis and reactions of the ...... the carcinogen benzo[a]pyrene.
@en
Synthesis and reactions of the ...... the carcinogen benzo[a]pyrene.
@nl
prefLabel
Synthesis and reactions of the ...... the carcinogen benzo[a]pyrene.
@en
Synthesis and reactions of the ...... the carcinogen benzo[a]pyrene.
@nl
P2093
P356
P1476
Synthesis and reactions of the ...... the carcinogen benzo[a]pyrene.
@en
P2093
P304
P356
10.1021/JA00447A053
P407
P577
1977-03-01T00:00:00Z