Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter.
about
Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugsAbolished cocaine reward in mice with a cocaine-insensitive dopamine transporterRecognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transportersComputational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.Cocaine-insensitive dopamine transporters with intact substrate transport produced by self-administration.Interaction of tyrosine 151 in norepinephrine transporter with the 2β group of cocaine analog RTI-113.How dopamine transporter interacts with dopamine: insights from molecular modeling and simulation.Recent progress in structure-function analyses of Nramp proton-dependent metal-ion transporters.Astrocytic control of synaptic transmission and plasticity: a target for drugs of abuse?Functional mutations in mouse norepinephrine transporter reduce sensitivity to cocaine inhibition.A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation.Mechanism for cocaine blocking the transport of dopamine: insights from molecular modeling and dynamics simulationsMutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine.Restoration of cocaine stimulation and reward by reintroducing wild type dopamine transporter in adult knock-in mice with a cocaine-insensitive dopamine transporter.Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding.Analysis of transmembrane domain 2 of rat serotonin transporter by cysteine scanning mutagenesis.Proline mutations induce negative-dosage effects on uptake velocity of the dopamine transporter.A genetic screen in Caenorhabditis elegans for dopamine neuron insensitivity to 6-hydroxydopamine identifies dopamine transporter mutants impacting transporter biosynthesis and trafficking.Roles of transmembrane domain 2 and the first intracellular loop in human noradrenaline transporter function: pharmacological and SCAM analysis.Inactivation of the catalytic phosphatase domain of PTPRT/RPTPρ increases social interaction in mice.
P2860
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P2860
Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Cocaine affinity decreased by ...... ain 2 of dopamine transporter.
@en
Cocaine affinity decreased by ...... ain 2 of dopamine transporter.
@nl
type
label
Cocaine affinity decreased by ...... ain 2 of dopamine transporter.
@en
Cocaine affinity decreased by ...... ain 2 of dopamine transporter.
@nl
prefLabel
Cocaine affinity decreased by ...... ain 2 of dopamine transporter.
@en
Cocaine affinity decreased by ...... ain 2 of dopamine transporter.
@nl
P356
P1476
Cocaine affinity decreased by ...... ain 2 of dopamine transporter.
@en
P2093
Howard H Gu
Xiaohong Wu
P304
P356
10.1124/MOL.63.3.653
P577
2003-03-01T00:00:00Z