Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy.
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Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6Improvement of morphine-mediated analgesia by inhibition of β-arrestin2 expression in mice periaqueductal gray matterChronic morphine induces up-regulation of the pro-apoptotic Fas receptor and down-regulation of the anti-apoptotic Bcl-2 oncoprotein in rat brainMonoamine neurotransmitters as substrates for novel tick sulfotransferases, homology modeling, molecular docking, and enzyme kinetics.G-protein coupled receptor kinases as modulators of G-protein signalling.Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling.μ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization.Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence.Morphine induces μ opioid receptor endocytosis in guinea pig enteric neurons following prolonged receptor activationFunctional selectivity and time-dependence of μ-opioid receptor desensitization at nerve terminals in the mouse ventral tegmental areaG-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal.Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to humanDownregulation of Spinal G Protein-Coupled Kinase 2 Abolished the Antiallodynic Effect of ElectroacupunctureDesensitization and trafficking of μ-opioid receptors in locus ceruleus neurons: modulation by kinases.Mu opioid receptor stimulation activates c-Jun N-terminal kinase 2 by distinct arrestin-dependent and independent mechanisms.Altered gating of opiate receptor-modulated K+ channels on amygdala neurons of morphine-dependent rats.Distinct effects of individual opioids on the morphology of spines depend upon the internalization of mu opioid receptorsMu-opioid receptor desensitization: is morphine different?Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons.The absence of endogenous beta-endorphin selectively blocks phosphorylation and desensitization of mu opioid receptors following partial sciatic nerve ligation.Mu opioid receptor activation of ERK1/2 is GRK3 and arrestin dependent in striatal neuronsRegulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.Post-activation-mediated changes in opioid receptors detected by N-terminal antibodies.Ligand-induced μ opioid receptor internalization in enteric neurons following chronic treatment with the opiate fentanylChronic morphine treatment reduces recovery from opioid desensitization.Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestinsMorphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons.Regulation of opioid receptors by endocytic membrane traffic: mechanisms and translational implications.Regulation of opioid receptor signalling: implications for the development of analgesic tolerance.β-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia.Differential desensitization observed at multiple effectors of somatic mu opioid receptors underlies sustained agonist-mediated inhibition of proopiomelanocortin neuron activity.Morphine-induced mu opioid receptor trafficking enhances reward yet prevents compulsive drug use.Agonist-dependent postsynaptic effects of opioids on miniature excitatory postsynaptic currents in cultured hippocampal neurons.Identification of a potent and highly efficacious, yet slowly desensitizing CB1 cannabinoid receptor agonist.Spinal or supraspinal phosphorylation deficiency at the MOR C-terminus does not affect morphine tolerance in vivo.
P2860
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P2860
Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Agonist induced homologous des ...... dependent on agonist efficacy.
@en
Agonist induced homologous des ...... dependent on agonist efficacy.
@nl
type
label
Agonist induced homologous des ...... dependent on agonist efficacy.
@en
Agonist induced homologous des ...... dependent on agonist efficacy.
@nl
prefLabel
Agonist induced homologous des ...... dependent on agonist efficacy.
@en
Agonist induced homologous des ...... dependent on agonist efficacy.
@nl
P2093
P1476
Agonist induced homologous des ...... dependent on agonist efficacy
@en
P2093
P304
P577
1998-10-01T00:00:00Z