Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough. - Wikidata - awgldk - TriplyDB

Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough.

Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough.

http://www.wikidata.org/entity/Q44391294

about

Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection Hierarchical docking of databases of multiple ligand conformations Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins Bacillus anthracis edema factor substrate specificity: evidence for new modes of action A 1.3-Å Structure of Zinc-bound N-terminal Domain of Calmodulin Elucidates Potential Early Ion-binding Step Lethal and edema toxins in the pathogenesis of Bacillus anthracis septic shock: implications for therapy Bacillus anthracis edema toxin impairs neutrophil actin-based motility Anthrax toxins induce shock in rats by depressed cardiac ventricular function Docking Screens for Novel Ligands Conferring New Biology.Molecular motions as a drug target: mechanistic simulations of anthrax toxin edema factor function led to the discovery of novel allosteric inhibitors.Peptide inhibitors MAP the way towards fighting anthrax pathogenesis.Novel inhibitors of anthrax edema factor.Comparison of three anthrax toxin neutralization assays Structure-based discovery of A2A adenosine receptor ligands.Identification of Small Molecule Inhibitors of Clostridium perfringens ε-Toxin Cytotoxicity Using a Cell-Based High-Throughput Screen Contributions of edema factor and protective antigen to the induction of protective immunity by Bacillus anthracis edema toxin as an intranasal adjuvant Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor.Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.Structural basis of anthrax edema factor neutralization by a neutralizing antibody Bis-halogen-anthraniloyl-substituted nucleoside 5'-triphosphates as potent and selective inhibitors of Bordetella pertussis adenylyl cyclase toxin.MyD88-dependent signaling protects against anthrax lethal toxin-induced impairment of intestinal barrier function.Designing inhibitors of anthrax toxin Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice A Bacillus anthracis strain deleted for six proteases serves as an effective host for production of recombinant proteins Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor Mouse monoclonal antibodies to anthrax edema factor protect against infection.Anthrax edema toxin impairs clearance in mice.Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin.Antitoxins: novel strategies to target agents of bioterrorism.The evolving field of biodefence: therapeutic developments and diagnostics.Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo.Statistical analysis, optimization, and prioritization of virtual screening parameters for zinc enzymes including the anthrax toxin lethal factor.New insights into the pathogenesis and treatment of anthrax toxin-induced shock.The adenylyl cyclase activity of anthrax edema factor.Targeting bacterial toxins.Dual myxovirus screen identifies a small-molecule agonist of the host antiviral response.Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides.Adenylyl and guanylyl cyclase assays.

P2860

Q24295132-66A66825-7536-41BA-ACA5-9D1F82EEFC5C Q24311064-F957C349-FC1C-42BA-B2F0-C3EE27C05426 Q24538548-E16E6710-F73E-4CAD-AA13-68861BB93108 Q24562788-520FB684-89F5-4C44-9A71-1C76F0FF499C Q27000357-7D6D24EC-70A9-4CF7-9708-F940FA4A965B Q27648809-282233DD-F72D-441D-94E3-19771C05A42B Q28383094-E7C7AC37-E7E8-4899-A6D5-2DCCD06B54FE Q28388945-EB5BEDFC-279D-4467-8F64-57D1CC59C3DD Q28469210-219C4F44-746C-41C4-BE4C-1B0CA9F5133F Q30489011-F69E1945-44AF-4551-919D-6220A6BB81BE Q30570720-F395FE39-66D8-4C23-896A-32DD3AA9E016 Q33236706-A8CCB966-ADF3-4F83-9340-E8855532B0D7 Q33351165-7731F5F5-5572-4E6D-AF92-2A55B2551734 Q33550670-EECE418B-F6EE-4164-ACFB-D83E99626BDD Q33560239-9C619523-142F-47D8-BEA3-B54CFB4A409D Q33664738-2FA344BB-186A-4691-9FAF-E1D4AD5A64A5 Q33741147-F0347A95-5BB1-4EA3-9848-E011EA018D1A Q33953010-33BCFAEE-C9AB-42EE-9DDE-91EFAB0ED808 Q33978117-7EB53ECB-11EF-42CF-B8CA-305578587C59 Q34095681-4F405632-D543-45AA-9B25-FC79FE27ACFA Q34458609-678166E0-D440-4E78-9C00-C91EBA8BF3CE Q34484447-DB165F34-DE31-4F25-BD65-214216438024 Q35018313-705932AF-0BBB-4C97-AFC8-AA6F751C9431 Q35085358-0E7CB211-E4E3-4964-961F-E6E96F72CE75 Q35243734-4C7A7AA9-0EE6-4AD6-8F51-24420F54975D Q35623187-AE6D7EE7-6F18-4426-BAB0-AA5F636A67D4 Q35671649-003251B4-44C2-4AD2-BE68-C9CC0F7182C4 Q35689507-DEB37D23-2D44-418F-A023-949BA0758214 Q35784180-19C7DA4C-62E8-407E-898E-DF52694B5252 Q35889591-C3F8EC92-F7CC-4759-8643-BB4DED6F6A1B Q36085668-3C3513BC-2FC9-4535-A02C-EEF4881CE4FF Q36228556-C4BF5408-E413-4C8F-A053-2A13ACB375E7 Q36243872-80726975-289E-4AFC-BFFC-84D2018B510F Q36842720-7161A1B8-1377-499C-A10F-E1C4EE35E63D Q37439070-6AA134D3-8AF3-4669-A7A7-F0B818431B5E Q37996325-1FC3443A-E543-45B9-81CF-1D37F8321B7A Q39113607-C8F27515-6E0E-44D5-ADB1-1ED753A8698F Q40586309-F5AD237D-63ED-4153-9284-08643AD47C88 Q42726544-FAD10AB5-ACAF-499A-AA4C-3E8F6EB92315

P2860

Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough.

http://www.wikidata.org/entity/Q44391294

description

2003 nî lūn-bûn

@nan

2003年の論文

@ja

2003年学术文章

@wuu

2003年学术文章

@zh

2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

2003年學術文章

@zh-hant

name

Structure-based inhibitor disc ...... se anthrax and whooping cough.

@en

Structure-based inhibitor disc ...... se anthrax and whooping cough.

@nl

type

label

Structure-based inhibitor disc ...... se anthrax and whooping cough.

@en

Structure-based inhibitor disc ...... se anthrax and whooping cough.

@nl

prefLabel

Structure-based inhibitor disc ...... se anthrax and whooping cough.

@en

Structure-based inhibitor disc ...... se anthrax and whooping cough.

@nl

P1433

Q44391294-0691A670-6EFB-451D-93F1-FB1FFAF53A16

P1476

Q44391294-B5E6E8B8-B3D0-4638-BAD3-50A8FABFE4CC

P2093

Q44391294-0FA60188-BA6B-45D3-8020-12E2273DB888

Q44391294-181BACF5-C6D7-4BB7-8881-E9C2D2A4FEA9

Q44391294-1F680134-5682-4CA5-911E-7117EF3D8DD8

Q44391294-D4D00640-5FBC-4817-A667-BDB700E9884D

Q44391294-D7845DB2-3929-47BC-95B4-E7B26A0D467D

Q44391294-F367D363-91D8-4A2F-9C22-B9C6025A9A0B

P2860

Q44391294-05673AFB-CFA0-42E7-929B-6F1256E70229

Q44391294-061F0178-346F-466E-9EAD-7E96AE577D9A

Q44391294-076045E5-0BBE-4C80-9242-39707D0E4352

Q44391294-0AA94CBF-ADBB-481D-B61A-DCF38948A475

Q44391294-0E1FE4F2-3D78-4013-A61A-36EA58A8B02C

Q44391294-1E358CE4-B1D8-406A-B71A-8C7D162DE572

Q44391294-21A45AC1-B0EE-4977-9787-B16B81F2EECE

Q44391294-272E8765-2E1F-4AF5-BCA0-470350F69B2B

Q44391294-29D846FB-6865-43C7-A2FE-168B34D5649A

Q44391294-3671B195-4844-43D9-AFC6-91FD039612A6

P304

Q44391294-ADE377D8-DAC3-409F-A20A-5D7883907D77

P31

Q44391294-BC1EE0FD-8B7D-455C-BE4B-54EE3786E193

P356

Q44391294-DF674FC8-78B7-4961-8287-7E1A676F22D7

P407

Q44391294-609901E3-7620-4E4A-9000-C177500CCFAE

P433

Q44391294-D905C90D-DEA1-42D6-AE84-4DF0458DFE3E

P478

Q44391294-732ED5C4-0AD5-4D3E-842B-23B5FE2CF682

P50

Q44391294-26AB695B-7055-46F7-8A87-ED14E7E80884

Q44391294-4D5C37C3-72F8-4455-8A6E-128F74905815

P577

Q44391294-911722D3-78FC-4AEA-B4B7-FB87C9EB92BD

P698

Q44391294-ACE63E6E-AB5F-47A5-99A3-E6AE16905B3B

P356

P1433

Journal of Biological Chemistry

P1476

Structure-based inhibitor disc ...... se anthrax and whooping cough.

@en

P2093

Binqing Q Wei

http://www.w3.org/2001/XMLSchema#string

Brian K Shoichet

http://www.w3.org/2001/XMLSchema#string

Pamela Bergson

http://www.w3.org/2001/XMLSchema#string

Sandriyana Soelaiman

http://www.w3.org/2001/XMLSchema#string

Young-Sam Lee

http://www.w3.org/2001/XMLSchema#string

Yuequan Shen

http://www.w3.org/2001/XMLSchema#string

P2860

Genome sequence of Yersinia pestis, the causative agent of plague

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin

Molecular basis for P-site inhibition of adenylyl cyclase

Crystal structure of the anthrax lethal factor

Structure-based discovery of a novel, noncovalent inhibitor of AmpC beta-lactamase

A model binding site for testing scoring functions in molecular docking

Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins

Crystal structure of the anthrax toxin protective antigen

Identification of the cellular receptor for anthrax toxin

P304

25990-25997

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M301232200

http://www.w3.org/2001/XMLSchema#string

P407

P433

28

http://www.w3.org/2001/XMLSchema#string

P478

278

http://www.w3.org/2001/XMLSchema#string

P50

P577

2003-04-03T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

12676933

http://www.w3.org/2001/XMLSchema#string