Structural features of human initiation factor 4E, studied by X-ray crystal analyses and molecular dynamics simulations.
about
Eukaryotic translation initiation is controlled by cooperativity effects within ternary complexes of 4E-BP1, eIF4E, and the mRNA 5' capStructural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton proteinWeak binding affinity of human 4EHP for mRNA cap analogsThe Structure of Eukaryotic Translation Initiation Factor-4E from Wheat Reveals a Novel Disulfide BondStructural Insights into Parasite eIF4E Binding Specificity for m7G and m2,2,7G mRNA CapsCrystal structure of a minimal eIF4E-Cup complex reveals a general mechanism of eIF4E regulation in translational repressionStructural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiationStructural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4EeIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognitionContribution of trans-splicing, 5' -leader length, cap-poly(A) synergism, and initiation factors to nematode translation in an Ascaris suum embryo cell-free systemConformational changes in protein loops and helices induced by post-translational phosphorylation.The Distribution of eIF4E-Family Members across InsectaMNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages.Chemical synthesis and binding activity of the trypanosomatid cap-4 structure.Dynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap.Novel cap analogs for in vitro synthesis of mRNAs with high translational efficiency.Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NHDistinct features of cap binding by eIF4E1b proteinsSerotonin increases phosphorylation of synaptic 4EBP through TOR, but eukaryotic initiation factor 4E levels do not limit somatic cap-dependent translation in aplysia neurons.Characterization of native protein complexes using ultraviolet photodissociation mass spectrometry.Binding specificities and potential roles of isoforms of eukaryotic initiation factor 4E in LeishmaniaThe alveolate translation initiation factor 4E family reveals a custom toolkit for translational control in core dinoflagellatesMnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development.Evolutionary conservation and diversification of the translation initiation apparatus in trypanosomatids.Intrinsic RNA binding by the eukaryotic initiation factor 4F depends on a minimal RNA length but not on the m7G cap.Kinetic mechanism for the binding of eIF4F and tobacco Etch virus internal ribosome entry site rna: effects of eIF4B and poly(A)-binding protein.Cap and cap-binding proteins in the control of gene expression.RNA binding protein/RNA element interactions and the control of translationStopped-flow kinetic analysis of eIF4E and phosphorylated eIF4E binding to cap analogs and capped oligoribonucleotides: evidence for a one-step binding mechanism.Recognition of cap structure by influenza B virus RNA polymerase is less dependent on the methyl residue than recognition by influenza A virus polymerase.Ubiquitination and proteasome-dependent degradation of human eukaryotic translation initiation factor 4E.Insights into the molecular determinants involved in cap recognition by the vaccinia virus D10 decapping enzyme.High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translationKinetic mechanism for assembly of the m7GpppG.eIF4E.eIF4G complexStructure of a viral cap-independent translation element that functions via high affinity binding to the eIF4E subunit of eIF4F.Turnip mosaic virus genome-linked protein VPg binds C-terminal region of cap-bound initiation factor 4E orthologue without exhibiting host cellular specificity.Identification and bioinformatics characterization of translation initiation complex eIF4F components and poly(A)-binding protein from Plasmodium falciparum.Cap-binding activity of an eIF4E homolog from Leishmania.Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms: crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1.
P2860
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P2860
Structural features of human initiation factor 4E, studied by X-ray crystal analyses and molecular dynamics simulations.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Structural features of human i ...... olecular dynamics simulations.
@en
Structural features of human i ...... olecular dynamics simulations.
@nl
type
label
Structural features of human i ...... olecular dynamics simulations.
@en
Structural features of human i ...... olecular dynamics simulations.
@nl
prefLabel
Structural features of human i ...... olecular dynamics simulations.
@en
Structural features of human i ...... olecular dynamics simulations.
@nl
P2093
P1476
Structural features of human i ...... olecular dynamics simulations.
@en
P2093
Hiroo Miyagawa
Kin-ichiro Miura
Koji Tomoo
Koumei Okabe
Kunihiro Kitamura
Masahiro Sasaki
Shigenobu Morino
Shoichi Fukuhara
Taizo Taniguchi
Toshimasa Ishida
P304
P356
10.1016/S0022-2836(03)00314-0
P407
P577
2003-04-01T00:00:00Z