IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils.
about
PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancersTargeting the Pim kinases in multiple myelomaThe PIM kinases in hematological cancersCell and gene therapy for severe heart failure patients: the time and place for Pim-1 kinase.Basophil modulation by cytokine instruction.The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling.Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survivalSignaling pathways activated by a protease allergen in basophils.Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival.Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergyExpression profiling of human basophils: modulation by cytokines and secretagoguesReduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice.iNKT Cells Are Responsible for the Apoptotic Reduction of Basophils That Mediate Th2 Immune Responses Elicited by Papain in Mice Following γPGA Stimulation.Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33.The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease.IL-3 promotes the development of experimental autoimmune encephalitis.A progenitor cell origin of myeloid malignanciesThe JAK2V617 mutation induces constitutive activation and agonist hypersensitivity in basophils from patients with polycythemia veraBasophils as critical orchestrators of Th2-type immune responses.Inflammation and survival pathways: chronic lymphocytic leukemia as a model system.Why target PIM1 for cancer diagnosis and treatment?The role of basophils in the pathogenesis of allergic disease.The GM-CSF receptor family: mechanism of activation and implications for disease.Potential role of histamine releasing factor (HRF) as a therapeutic target for treating asthma and allergy.New insights into basophil heterogeneity.Selective JAK2 inhibition specifically decreases Hodgkin lymphoma and mediastinal large B-cell lymphoma growth in vitro and in vivo.Human Basophils Modulate Plasma Cell Differentiation and Maturation.Anti-Fas/CD95 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) differentially regulate apoptosis in normal and neoplastic human basophils.Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3.Balance between IL-3 and type Iinterferons and their interrelationship with FasL dictates lifespan and effector functions of human basophils.Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxisThe PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.The Evolution of Human Basophil Biology from Neglect towards Understanding of Their Immune FunctionsDevelopment of a microarray-based method to detect exposure of human basophils to IL-3.Roles for the High Affinity IgE Receptor, FcεRI, of Human Basophils in the Pathogenesis and Therapy of Allergic Asthma: Disease Promotion, Protection or Both?Basophils are not the key antigen-presenting cells in allergic patientsIn vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8.BH3 mimetics efficiently induce apoptosis in mouse basophils and mast cells.History of Histamine-Releasing Factor (HRF)/Translationally Controlled Tumor Protein (TCTP) Including a Potential Therapeutic Target in Asthma and Allergy.IL-3 Is a Marker of Encephalitogenic T Cells, but Not Essential for CNS Autoimmunity.
P2860
Q24603099-5C26EA0A-2B83-460D-8CA4-BD2A75B3E821Q26799499-D8A6C8EA-B5D4-48C9-96CD-6CD98825598BQ28258028-F2057473-7A5F-45E2-902D-112EDD46B063Q34075071-6CECA596-CD1D-465C-AE4B-5856C0239F22Q34304314-FD566781-A570-492A-97B0-E75A7355FE4EQ34304678-9C6324B5-890C-4D06-BE23-31378BF22898Q34430434-162BE70F-302D-4C10-8F1D-6A6049383762Q34581292-76E95EF0-427C-44EB-B3E5-552A6995FE7FQ34886884-09A3671B-F3E9-401B-891C-651CCE84D0B7Q35546493-F4E3A099-AF25-4E94-A791-12C6C68064F1Q35626987-2BA8AACB-DAD0-4D37-BDA1-6CA17DC9F1B0Q35631334-804B34A4-A8D5-401F-8B4E-E84A63471BBFQ35980868-87C4C212-05D2-495E-A490-AEEF84AC09CFQ37100750-03DA4B1F-015F-4338-BB46-59769DB87784Q37306641-7E2C1DFC-305A-4589-9B02-07080CB257A2Q37316231-063EB29B-1B49-4E04-BDA6-0ACADA120D28Q37377284-11A15B45-F692-48FE-9EFB-82CFC10EC2B0Q37406784-1CD71AB8-EDB4-4CDB-B52D-42B3341A4C4BQ37755330-CE3DAD10-E313-4490-8575-78486553D414Q37778876-A2201FB0-199C-46A2-A8D1-0D0A11D4DB5AQ37797472-C26FB28D-CD38-4382-B81C-D0EC564F9B99Q37875210-249FE35B-FA5E-475F-BD3C-D90FAF4374D3Q37976887-0E9E7F71-7938-480F-B57B-D03D1DD5AC5DQ38051310-7A6B31BE-ECDC-4326-810F-1E53776503DDQ38834168-CDA2C75E-6DB6-4229-A6A6-91769650514EQ39017147-4029BFE5-9662-49C0-8C60-FF3A2C891B62Q39182500-A0E912A1-EA70-4987-90FB-9DB5853F8F71Q39276326-9F5D1757-DBA2-4ADD-8ADF-A9B62528EB3CQ39901791-3C107B11-FA41-4F8B-BBDC-083B5D4D3AC5Q40445161-C99DC756-716F-428E-B567-FB251A150F77Q41633025-34BE999F-B84F-42E1-A23C-1A0E524A81E1Q41733002-4656E348-A5A1-4487-968C-2096B8551E7CQ42335943-627E677B-2353-4409-85B3-64C5522BF1C0Q42350803-22986AF2-B4A9-49E6-BE04-F85D433EF736Q42462067-84C9503F-13F7-4B93-ADDD-4F6F44D53FB8Q42591766-C657A7DA-B558-4A9B-AD33-19FE56194FBEQ46014710-9B76648E-5461-438A-ABC0-54AF06E30B01Q47119167-7D14E83D-B8A3-42F1-8D44-781B8B28D2FAQ47391528-96B09DC2-636F-48AA-979B-E53D041C3EADQ55306339-541F0B41-0C6C-4008-A2E6-21A99F1D7A7B
P2860
IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils.
@en
IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils.
@nl
type
label
IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils.
@en
IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils.
@nl
prefLabel
IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils.
@en
IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils.
@nl
P2093
P1433
P1476
IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils.
@en
P2093
Clemens A Dahinden
Nicole Spiegl
Svetlana A Didichenko
Thomas Brunner
P304
P356
10.1182/BLOOD-2008-04-149419
P407
P577
2008-09-02T00:00:00Z