Novel role of 3-phosphoglycerate kinase, a glycolytic enzyme, in the activation of L-nucleoside analogs, a new class of anticancer and antiviral agents.
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Molecular insights on pathogenic effects of mutations causing phosphoglycerate kinase deficiencyA spring-loaded release mechanism regulates domain movement and catalysis in phosphoglycerate kinaseEnzymology of purine and pyrimidine antimetabolites used in the treatment of cancerNonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosidesConformational dynamics in phosphoglycerate kinase, an open and shut case?Molecular basis for the lack of enantioselectivity of human 3-phosphoglycerate kinaseNucleoside diphosphate kinase and the activation of antiviral phosphonate analogs of nucleotides: binding mode and phosphorylation of tenofovir derivativesDevelopment of New Deoxycytidine Kinase Inhibitors and Noninvasive in Vivo Evaluation Using Positron Emission TomographyAn allosteric signaling pathway of human 3-phosphoglycerate kinase from force distribution analysisSynergistic activity of troxacitabine (Troxatyl) and gemcitabine in pancreatic cancerBehavior of thymidylate kinase toward monophosphate metabolites and its role in the metabolism of 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methyluracil (Clevudine) and 2',3'-didehydro-2',3'-dideoxythymidine in cells.UMP/CMPK is not the critical enzyme in the metabolism of pyrimidine ribonucleotide and activation of deoxycytidine analogs in human RKO cellsPDGF beta targeting in cervical cancer cells suggest a fine-tuning of compensatory signalling pathways to sustain tumourigenic stimulationComparison of the phosphorylation of 4'-ethynyl 2',3'-dihydro-3'-deoxythymidine with that of other anti-human immunodeficiency virus thymidine analogs.Antivirals and antiviral strategies.Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.Evaluation of the L-stereoisomeric nucleoside analog troxacitabine for the treatment of acute myeloid leukemia.Troxacitabine in acute leukemia.Troxacitabine in leukemia.Fluorinated Nucleosides: Synthesis and Biological ImplicationGlycolytic genes in cancer cells are more than glucose metabolic regulators.Understanding the molecular basis of HBV drug resistance by molecular modeling.1H, 15N, 13C backbone resonance assignments of human phosphoglycerate kinase in a transition state analogue complex with ADP, 3-phosphoglycerate and magnesium trifluoride.Substrate-induced double sided H-bond network as a means of domain closure in 3-phosphoglycerate kinase.Affinity of (alpha-P-borano)-NTP analogs to rabbit muscle pyruvate kinase.Co-opting ATP-generating glycolytic enzyme PGK1 phosphoglycerate kinase facilitates the assembly of viral replicase complexes.
P2860
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P2860
Novel role of 3-phosphoglycerate kinase, a glycolytic enzyme, in the activation of L-nucleoside analogs, a new class of anticancer and antiviral agents.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Novel role of 3-phosphoglycera ...... ticancer and antiviral agents.
@en
Novel role of 3-phosphoglycera ...... ticancer and antiviral agents.
@nl
type
label
Novel role of 3-phosphoglycera ...... ticancer and antiviral agents.
@en
Novel role of 3-phosphoglycera ...... ticancer and antiviral agents.
@nl
prefLabel
Novel role of 3-phosphoglycera ...... ticancer and antiviral agents.
@en
Novel role of 3-phosphoglycera ...... ticancer and antiviral agents.
@nl
P2093
P2860
P356
P1476
Novel role of 3-phosphoglycera ...... ticancer and antiviral agents.
@en
P2093
Elizabeth A Gullen
Ginger E Dutschman
Preethi Krishnan
Susan P Grill
Yung-Chi Cheng
P2860
P304
36726-36732
P356
10.1074/JBC.M307052200
P407
P577
2003-07-16T00:00:00Z