A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex.
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The WASP and WAVE family proteinsActivation of Arp2/3 complex: addition of the first subunit of the new filament by a WASP protein triggers rapid ATP hydrolysis on Arp2Interaction of SPIN90 with the Arp2/3 complex mediates lamellipodia and actin comet tail formationProtein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASPA hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome proteinHuman subtelomeric WASH genes encode a new subclass of the WASP familyStructural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNTStructure and control of the actin regulatory WAVE complexThe state of the filament.A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanismPhosphoregulation of the WAVE regulatory complex and signal integrationStructure and Biochemical Properties of Fission Yeast Arp2/3 Complex Lacking the Arp2 SubunitStructural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFUStructural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complexUnfolding of the C-Terminal Domain of the J-Protein Zuo1 Releases Autoinhibition and Activates Pdr1-Dependent TranscriptionSubstrate-Activated Conformational Switch on Chaperones Encodes a Targeting Signal in Type III SecretionStructural basis for regulation of Arp2/3 complex by GMFEffects of Arp2 and Arp3 nucleotide-binding pocket mutations on Arp2/3 complex function.Mechanism of a concentration-dependent switch between activation and inhibition of Arp2/3 complex by coroninControl of polarized assembly of actin filaments in cell motilityRole and structural mechanism of WASP-triggered conformational changes in branched actin filament nucleation by Arp2/3 complexPhysical mechanisms of signal integration by WASP family proteins.Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration.Interactions with actin monomers, actin filaments, and Arp2/3 complex define the roles of WASP family proteins and cortactin in coordinately regulating branched actin networksA novel role for WAVE1 in controlling actin network growth rate and architecture.Urea-Dependent Adenylate Kinase Activation following Redistribution of Structural States.Current and emerging treatment options for Wiskott-Aldrich syndrome.Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation.Mapping the interaction surface of a membrane protein: unveiling the conformational switch of phospholamban in calcium pump regulation.Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly.Actin-based motility of Burkholderia thailandensis requires a central acidic domain of BimA that recruits and activates the cellular Arp2/3 complex.Prediction and dissection of widely-varying association rate constants of actin-binding proteinsThe pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalencyActin binding to the central domain of WASP/Scar proteins plays a critical role in the activation of the Arp2/3 complex.Identification of motifs of Burkholderia pseudomallei BimA required for intracellular motility, actin binding, and actin polymerization.Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathwayArp2/3 complex is bound and activated by two WASP proteins.Structural analysis of the transitional state of Arp2/3 complex activation by two actin-bound WCAs.Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometrySignalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex.
P2860
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P2860
A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
A conserved amphipathic helix ...... activation of Arp2/3 complex.
@en
A conserved amphipathic helix ...... activation of Arp2/3 complex.
@nl
type
label
A conserved amphipathic helix ...... activation of Arp2/3 complex.
@en
A conserved amphipathic helix ...... activation of Arp2/3 complex.
@nl
prefLabel
A conserved amphipathic helix ...... activation of Arp2/3 complex.
@en
A conserved amphipathic helix ...... activation of Arp2/3 complex.
@nl
P2093
P356
P1476
A conserved amphipathic helix ...... activation of Arp2/3 complex.
@en
P2093
Donald A Kaiser
Eduardo Torres
Michael K Rosen
Sanjay C Panchal
P304
P356
10.1038/NSB952
P577
2003-08-01T00:00:00Z