Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium. - Wikidata - awgldk - TriplyDB

Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium.

Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium.

http://www.wikidata.org/entity/Q44552168

about

Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused review TNNI3K is a novel mediator of myofilament function and phosphorylates cardiac troponin I The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling Why does troponin I have so many phosphorylation sites? Fact and fancy Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation A preferred AMPK phosphorylation site adjacent to the inhibitory loop of cardiac and skeletal troponin I Acceleration of stretch activation in murine myocardium due to phosphorylation of myosin regulatory light chain Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response NOS1 induces NADPH oxidases and impairs contraction kinetics in aged murine ventricular myocytes.TNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships.PKCβII modulation of myocyte contractile performance.Inotropes do not increase mortality in advanced heart failure Phosphorylation of cardiac troponin I at protein kinase C site threonine 144 depresses cooperative activation of thin filaments.Calcium sensitivity, force frequency relationship and cardiac troponin I: critical role of PKA and PKC phosphorylation sites Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness Combined troponin I Ser-150 and Ser-23/24 phosphorylation sustains thin filament Ca(2+) sensitivity and accelerates deactivation in an acidic environment.Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.Ligation of the left circumflex coronary artery with subsequent MRI and histopathology in rabbits.Novel function of cardiac protein kinase D1 as a dynamic regulator of Ca2+ sensitivity of contraction Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury.Beneficial effects of SR33805 in failing myocardium.Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes.Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C.Augmented phosphorylation of cardiac troponin I in hypertensive heart failure.Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy.Single amino acid sequence polymorphisms in rat cardiac troponin revealed by top-down tandem mass spectrometry.In vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated.Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium.Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies.Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth.Post-translational modifications of myofilament proteins involved in length-dependent prolongation of relaxation in rabbit right ventricular myocardium Myofilament incorporation and contractile function after gene transfer of cardiac troponin I Ser43/45Ala.G-protein coupled receptor signaling in myocardium: not for the faint of heart.p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility.Functionally conservative substitutions at cardiac troponin I S43/45.Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes

P2860

Q21129229-83D7B9A4-74DA-47CC-9533-A7459E54DCFA Q24312834-7C058D40-CE9E-4B99-82BB-8EE466B091FE Q24643958-52F4036F-E383-4461-9384-E364C02E4290 Q28237326-A4068BF2-DE46-4A18-9A56-D945097AB422 Q28238928-181F0CD1-95C1-409A-BB52-CFE62031169C Q28268017-B191B7A8-A5F3-4F88-A22F-9E446D113CDF Q28274412-BAEBF1A9-7C1C-46D4-AAF1-A3E20A75F2D3 Q28304945-78917E52-23A0-4BB6-81E0-5DFC1C6FE686 Q28307636-5F441EE1-7EC8-43D7-B275-642555F7EA8C Q28510291-867F9D9D-7AEC-4D26-995F-4378C8134807 Q28569756-45DAEBFC-B01B-489C-9236-3563F07115AA Q30316375-E82D16B8-367A-421C-92F4-C2C438BF8EC3 Q30380968-61C7AC40-FE43-4B48-A574-FA16D758022D Q30524184-B50F1643-38EE-46C0-844A-C2806CEB0AB1 Q33685748-A2BD7A3F-F2CD-4912-9099-B67BAB92FF2C Q33782408-32F24EBC-FF90-4544-9E43-934D74CB5FFE Q33787533-B6486236-D9AA-4778-95E4-C20F05623E10 Q33787977-86959977-C728-4F76-A200-126CEDCF67AE Q33821210-87DFA0CE-D163-40A5-B016-246B795B603A Q33822294-0DD58A56-8003-4FF2-AC34-D839083094E9 Q34362493-E3B98B79-2ED6-4E34-9F05-6F715A56957A Q34438891-04B9F99D-FBFA-45B0-B9AB-6831505637EC Q34786395-0B2F05F5-6A9D-45AE-8191-8E29F1994A77 Q35114766-8EDACCF6-74D6-4C9D-A878-34285A84ECC2 Q35140062-7AA6CD34-D89C-4189-99E6-341700BEDC2B Q35158657-2A345BBA-A712-4DD8-8324-895501F63B24 Q35668835-CECE3CFA-8340-45F8-BD67-4E00191F156B Q35694064-06C870AA-0A74-4E20-B042-067726D62603 Q35852956-5E585BB4-51A7-4196-BE9A-DD88DB4815E5 Q35925687-560EDFE2-CEED-434E-9058-1CC2FECDFA80 Q36319816-B3E1F822-42DA-44AF-8987-341C5116105A Q36593277-F3D22EAD-DACB-4B5E-A04E-4D160A0A219D Q36599563-0B801EDE-4F5F-407F-8A8C-D5028ABE4638 Q36610320-85C9DDE1-DBB0-4F36-8A69-01811D18CE5D Q36807596-9C8EF247-057A-45E5-BE5A-56E310E78D8F Q36807617-F3758C3D-4AB2-4D8E-B593-C722470C96C5 Q36844422-0BCC9D0D-79B1-4DF9-B57F-C68257F3A0CF Q36869603-1F14152A-0852-4EC2-8219-57F24DF30A14 Q36984316-21E4D230-9EEE-406E-A35D-822BBBC64BA1 Q37086451-2FC1A665-90EA-45FA-AC6F-900F37036F19

P2860

Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium.

http://www.wikidata.org/entity/Q44552168

description

2003 nî lūn-bûn

@nan

2003年の論文

@ja

2003年学术文章

@wuu

2003年学术文章

@zh

2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

2003年學術文章

@zh-hant

name

Protein kinase C and A sites o ...... ivity in the mouse myocardium.

@en

Protein kinase C and A sites o ...... ivity in the mouse myocardium.

@nl

type

label

Protein kinase C and A sites o ...... ivity in the mouse myocardium.

@en

Protein kinase C and A sites o ...... ivity in the mouse myocardium.

@nl

prefLabel

Protein kinase C and A sites o ...... ivity in the mouse myocardium.

@en

Protein kinase C and A sites o ...... ivity in the mouse myocardium.

@nl

P1433

Q44552168-6D919B66-B553-4D52-923D-95E0F39E311B

P1476

Q44552168-17577C30-F662-409F-A3AF-822A3AEA6980

P2093

Q44552168-1C42D894-8413-4799-AD9A-FC2B4699F448

Q44552168-5E3332EF-7E02-4078-966F-3AB556840EE3

Q44552168-BC51F1F7-85C0-464C-AC17-166D12AE8C0E

Q44552168-BFF2699D-5425-4CDB-A209-514E7E34DE4C

Q44552168-EEFF218E-0790-4FF9-BF80-82A23516B449

P2860

Q44552168-03C92912-7BA9-4065-92B5-8EA572CD9659

Q44552168-20C7E28D-A92A-47C0-B1E3-13875CB2F20D

Q44552168-2639A3AD-137A-4B2C-B45D-80A3ECACF0D4

Q44552168-325E85BB-E7B8-4FB8-8954-AEEAF1D272A9

Q44552168-41E25678-F05F-4647-97D2-6D5C0F4C0F6B

Q44552168-43318406-8FDE-4AD8-AA9F-D7004916272F

Q44552168-46D9CEDC-4814-474C-870B-DC39771CB203

Q44552168-487C9918-98FA-4D2C-86EF-2242EB0942C5

Q44552168-4D54402E-D0D5-4E7D-B969-A815ECB0C3CB

Q44552168-5DE2A016-534D-4E28-9B40-3C5AF2263F04

P304

Q44552168-9E650ED7-53EF-4B46-9924-08F698FB3F13

P31

Q44552168-2782F173-AB22-4777-9C12-066545A00955

P356

Q44552168-DC519963-8078-4999-AB02-770400C306E0

P407

Q44552168-506FF695-787F-4052-962D-CED15E5DBF43

P433

Q44552168-746B43E2-FA35-4AB1-8C23-97DC83B46C96

P478

Q44552168-51913899-763F-4168-9C9E-D6F8E3F1B37C

P577

Q44552168-600E002F-045C-42E6-8770-2AEB9ECC217F

P5875

Q44552168-2AE647EB-6C58-4D22-BAF8-CB7683BEFDCE

P698

Q44552168-D48CC7D7-86A2-4720-B4D0-60AFD8F14153

P932

Q44552168-070923AD-EE97-440C-A3EC-F95330E8DE42

P356

JPHYSIOL.2003.045260

P1433

The Journal of Physiology

P1476

Protein kinase C and A sites o ...... ivity in the mouse myocardium.

@en

P2093

Dahua Zhang

http://www.w3.org/2001/XMLSchema#string

Hao Wang

http://www.w3.org/2001/XMLSchema#string

Jeffery W Walker

http://www.w3.org/2001/XMLSchema#string

Kara R Kemnitz

http://www.w3.org/2001/XMLSchema#string

YeQing Pi

http://www.w3.org/2001/XMLSchema#string

P2860

Transgenic incorporation of skeletal TnT into cardiac myofilaments blunts PKC-mediated depression of force

The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms

Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity

The effect of myosin light chain 2 dephosphorylation on Ca2+ -sensitivity of force is enhanced in failing human hearts

Arachidonic acid stimulates protein kinase C-epsilon redistribution in heart cells

Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties

Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1

Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants

The influence of P-light chain phosphorylation by myosin light chain kinase on the calcium sensitivity of chemically skinned heart fibres

PKA accelerates rate of force development in murine skinned myocardium expressing alpha- or beta-tropomyosin

P304

845-857

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1113/JPHYSIOL.2003.045260

http://www.w3.org/2001/XMLSchema#string

P407

P433

Pt 3

http://www.w3.org/2001/XMLSchema#string

P478

552

http://www.w3.org/2001/XMLSchema#string

P577

2003-08-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6257471

http://www.w3.org/2001/XMLSchema#string

P698

12923217

http://www.w3.org/2001/XMLSchema#string

P932

2343448

http://www.w3.org/2001/XMLSchema#string