Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium.
about
Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused reviewTNNI3K is a novel mediator of myofilament function and phosphorylates cardiac troponin IThe endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivoApelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanismsInhibition of PKC phosphorylation of cTnI improves cardiac performance in vivoDistinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cyclingWhy does troponin I have so many phosphorylation sites? Fact and fancyAblation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylationA preferred AMPK phosphorylation site adjacent to the inhibitory loop of cardiac and skeletal troponin IAcceleration of stretch activation in murine myocardium due to phosphorylation of myosin regulatory light chainDifferential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile responseNOS1 induces NADPH oxidases and impairs contraction kinetics in aged murine ventricular myocytes.TNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships.PKCβII modulation of myocyte contractile performance.Inotropes do not increase mortality in advanced heart failurePhosphorylation of cardiac troponin I at protein kinase C site threonine 144 depresses cooperative activation of thin filaments.Calcium sensitivity, force frequency relationship and cardiac troponin I: critical role of PKA and PKC phosphorylation sitesExcision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffnessCombined troponin I Ser-150 and Ser-23/24 phosphorylation sustains thin filament Ca(2+) sensitivity and accelerates deactivation in an acidic environment.Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.Ligation of the left circumflex coronary artery with subsequent MRI and histopathology in rabbits.Novel function of cardiac protein kinase D1 as a dynamic regulator of Ca2+ sensitivity of contractionOverexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury.Beneficial effects of SR33805 in failing myocardium.Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes.Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C.Augmented phosphorylation of cardiac troponin I in hypertensive heart failure.Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy.Single amino acid sequence polymorphisms in rat cardiac troponin revealed by top-down tandem mass spectrometry.In vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated.Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium.Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies.Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase AThe role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth.Post-translational modifications of myofilament proteins involved in length-dependent prolongation of relaxation in rabbit right ventricular myocardiumMyofilament incorporation and contractile function after gene transfer of cardiac troponin I Ser43/45Ala.G-protein coupled receptor signaling in myocardium: not for the faint of heart.p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility.Functionally conservative substitutions at cardiac troponin I S43/45.Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes
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P2860
Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Protein kinase C and A sites o ...... ivity in the mouse myocardium.
@en
Protein kinase C and A sites o ...... ivity in the mouse myocardium.
@nl
type
label
Protein kinase C and A sites o ...... ivity in the mouse myocardium.
@en
Protein kinase C and A sites o ...... ivity in the mouse myocardium.
@nl
prefLabel
Protein kinase C and A sites o ...... ivity in the mouse myocardium.
@en
Protein kinase C and A sites o ...... ivity in the mouse myocardium.
@nl
P2093
P2860
P1476
Protein kinase C and A sites o ...... ivity in the mouse myocardium.
@en
P2093
Dahua Zhang
Jeffery W Walker
Kara R Kemnitz
P2860
P304
P356
10.1113/JPHYSIOL.2003.045260
P407
P577
2003-08-15T00:00:00Z