HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death.
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The role of BH3-mimetic drugs in the treatment of pediatric hepatoblastomaCritical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitorSusceptibility of myelomonocytic leukemia U937 cells to the induction of apoptosis by the non-peptidic Bcl-2 ligand HA14-1 is cell cycle phase-dependent.B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins.Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment.Anaplastic lymphoma kinase and its signalling molecules as novel targets in lymphoma therapy.Casein induces the proliferation of bone marrow mononuclear cells, apoptosis of WEHI-3 leukaemic cells and increased survival in a leukaemia mouse model.Promotion of PDT efficacy by a Bcl-2 antagonist.Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism.Sequestering survivin to functionalized nanoparticles: a strategy to enhance apoptosis in cancer cellsTargeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysisUrinary levels of Bcl-2 are elevated in ovarian cancer patients.Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?Expanding circle of inhibition: small-molecule inhibitors of Bcl-2 as anticancer cell and antiangiogenic agents.Fruit extract from a Sechium edule hybrid induce apoptosis in leukaemic cell lines but not in normal cells.Apoptosis of t(14;18)-positive lymphoma cells by a Bcl-2 interacting small moleculeDual mechanisms of sHA 14-1 in inducing cell death through endoplasmic reticulum and mitochondria.sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell.Small-molecule Bcl-2 inhibitors sensitise tumour cells to immune-mediated destruction.A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2.Apoptosis sensitizers enhance cytotoxicity in hepatoblastoma cells.Effect of HA14-1 on apoptosis-regulating proteins in HeLa cells.Regulation of HA14-1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells.
P2860
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P2860
HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
HA14-1 selectively induces apo ...... cytarabine-induced cell death.
@en
HA14-1 selectively induces apo ...... cytarabine-induced cell death.
@nl
type
label
HA14-1 selectively induces apo ...... cytarabine-induced cell death.
@en
HA14-1 selectively induces apo ...... cytarabine-induced cell death.
@nl
prefLabel
HA14-1 selectively induces apo ...... cytarabine-induced cell death.
@en
HA14-1 selectively induces apo ...... cytarabine-induced cell death.
@nl
P2093
P2860
P356
P1433
P1476
HA14-1 selectively induces apo ...... cytarabine-induced cell death.
@en
P2093
Lickliter JD
Wickham NW
P2860
P2888
P304
P356
10.1038/SJ.LEU.2403102
P577
2003-11-01T00:00:00Z