Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?
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Estrogenic control of mitochondrial function and biogenesisHow cell death shapes cancerInteractions between mitochondria and the transcription factor myocyte enhancer factor 2 (MEF2) regulate neuronal structural and functional plasticity and metaplasticityCombination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expressionPan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cellsOncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-βBH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention.Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid.Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML.High-throughput screen for the chemical inhibitors of antiapoptotic bcl-2 family proteins by multiplex flow cytometry.Bim regulates alloimmune-mediated vascular injury through effects on T-cell activation and death.Ionizing radiation sensitizes breast cancer cells to Bcl-2 inhibitor, ABT-737, through regulating Mcl-1Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights.Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress.Potential therapeutic benefits of strategies directed to mitochondria.The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.Antioxidant activity and ultrastructural changes in gastric cancer cell lines induced by Northeastern Thai edible folk plant extractsAmphipathic tail-anchoring peptide and Bcl-2 homology domain-3 (BH3) peptides from Bcl-2 family proteins induce apoptosis through different mechanismsTargeting survivin in cancer: novel drug development approaches.Biological properties of carotenoids extracted from Halobacterium halobium isolated from a Tunisian solar saltern.Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitroOBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis.Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combinationSuppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad.Bim and Bmf in tissue homeostasis and malignant disease.The mitochondrial death pathway: a promising therapeutic target in diseasesSerum UCH-L1 as a Novel Biomarker to Predict Neuronal Apoptosis Following Deep Hypothermic Circulatory Arrest.The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skinApicidin and docetaxel combination treatment drives CTCFL expression and HMGB1 release acting as potential antitumor immune response inducers in metastatic breast cancer cells.ABT-737 synergizes with Bortezomib to kill melanoma cells.BH3-only protein bid participates in the Bcl-2 network in healthy liver cellsYM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context.Crude alkaloid extract of Rhazya stricta inhibits cell growth and sensitizes human lung cancer cells to cisplatin through induction of apoptosis.Apoptotic pathways in pancreatic ductal adenocarcinomaHDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses.A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.Counteracting the activation of pAkt by inhibition of MEK/Erk inhibition reduces actin disruption-mediated apoptosis in PTEN-null PC3M prostate cancer cell linesBcl2 family proteins in carcinogenesis and the treatment of cancer.Noxa: at the tip of the balance between life and death.Targeting the BCL-2 family in malignancies of germinal centre origin.
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Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 28 March 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Targeting the Bcl-2-regulated ...... through in anticancer therapy?
@en
Targeting the Bcl-2-regulated ...... through in anticancer therapy?
@nl
type
label
Targeting the Bcl-2-regulated ...... through in anticancer therapy?
@en
Targeting the Bcl-2-regulated ...... through in anticancer therapy?
@nl
prefLabel
Targeting the Bcl-2-regulated ...... through in anticancer therapy?
@en
Targeting the Bcl-2-regulated ...... through in anticancer therapy?
@nl
P2860
P356
P1476
Targeting the Bcl-2-regulated ...... through in anticancer therapy?
@en
P2093
A Villunger
F Baumgartner
P2860
P2888
P304
P356
10.1038/CDD.2008.37
P577
2008-03-28T00:00:00Z