Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas.
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Identification of novel candidate target genes in amplicons of Glioblastoma multiforme tumors detected by expression and CGH microarray profilingShould individual PI3 kinase isoforms be targeted in cancer?Targeting p110gamma in gastrointestinal cancers: attack on multiple frontsTargeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignanciesThe therapeutic potential of targeting the PI3K pathway in pediatric brain tumorsOncogenic mutations of PIK3CA in human cancersCancer associated E17K mutation causes rapid conformational drift in AKT1 pleckstrin homology (PH) domainMHC-restricted phosphopeptides from insulin receptor substrate-2 and CDC25b offer broad-based immunotherapeutic agents for cancer.Akt inhibitors: mechanism of action and implications for anticancer therapeutics.Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsyFish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth.Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer.Cytotoxic autophagy in cancer therapy.Constitutive AKT activation in follicular lymphoma.Akt: a double-edged sword in cell proliferation and genome stability.The class I PI3K/Akt pathway is critical for cancer cell survival in dogs and offers an opportunity for therapeutic interventionOncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinaseA biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.Somatic mutations of PIK3R1 promote gliomagenesis.Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase.Frontier of epilepsy research - mTOR signaling pathway.Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma.Leveraging metabolomics to assess the next generation of temozolomide-based therapeutic approaches for glioblastomasPI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Detailed characterization of alterations of chromosomes 7, 9, and 10 in glioblastomas as assessed by single-nucleotide polymorphism arrays.Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System.Brain tumours: classification and genesRadiosensitization of Primary Human Glioblastoma Stem-like Cells with Low-Dose AKT Inhibition.The sodium pump alpha1 subunit as a potential target to combat apoptosis-resistant glioblastomas.A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.p110δ PI3 kinase pathway: emerging roles in cancer.miR-21 Is Linked to Glioma Angiogenesis: A Co-Localization StudyRecent advances in molecular biology of thyroid cancer and their clinical implications.Targeting genomic alterations in squamous cell lung cancer.Irs2 inactivation suppresses tumor progression in Pten+/- mice.Class II phosphoinositide 3-kinase C2β regulates a novel signaling pathway involved in breast cancer progression.Gene amplification is a poor prognostic factor in anaplastic oligodendrogliomasPTEN and the PI3-kinase pathway in cancerCo-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish.Tumor necrosis factor-like weak inducer of apoptosis stimulation of glioma cell survival is dependent on Akt2 function.
P2860
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P2860
Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Genetic alterations and aberra ...... tion pathway in glioblastomas.
@en
Genetic alterations and aberra ...... tol-3'-kinase/protein kinase B
@nl
type
label
Genetic alterations and aberra ...... tion pathway in glioblastomas.
@en
Genetic alterations and aberra ...... tol-3'-kinase/protein kinase B
@nl
prefLabel
Genetic alterations and aberra ...... tion pathway in glioblastomas.
@en
Genetic alterations and aberra ...... tol-3'-kinase/protein kinase B
@nl
P1433
P1476
Genetic alterations and aberra ...... ction pathway in glioblastomas
@en
P2093
Christiane B Knobbe
Guido Reifenberger
P304
P356
10.1111/J.1750-3639.2003.TB00481.X
P577
2003-10-01T00:00:00Z