Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities.
about
Impaired immune responses and prolonged allograft survival in Sly1 mutant miceIs thymocyte development functional in the aged?Altered thymic positive selection and intracellular signals in Cbl-deficient miceQuestionable thymic nurse cell.Negative selection of thymocytes expressing the D10 TCREngagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4+CD8+ thymocytes into mature T cellsTwo distinct pathways of positive selection for thymocytes.Development of the CD4 and CD8 lineage of T cells: instruction versus selection.A special repertoire of alpha:beta T cells in neonatal mice.The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells.Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitroEarly molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, andPositive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47Constitutive expression of interleukin (IL)-4 in vivo causes autoimmune-type disorders in mice.Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus.Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic miceThe JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytesRegulation of AP-1 and NFAT transcription factors during thymic selection of T cells.Precommitment of CD4+CD8+ thymocytes to either CD4 or CD8 lineagesThe effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult miceSelective manipulation of the human T-cell receptor repertoire expressed by thymocytes in organ cultureNon-deletional mechanisms of peripheral and central tolerance: studies with transgenic mice with tissue-specific expression of a foreign MHC class I antigen.Differential role of the transcription factor NF-kappaB in selection and survival of CD4+ and CD8+ thymocytes.Instability of assembled T-cell receptor complex that is associated with rapid degradation of zeta chains in immature CD4+CD8+ thymocytes.Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression.A phorbol ester response element within the human T-cell receptor beta-chain enhancer.T and B cell tolerance and responses to viral antigens in transgenic mice: implications for the pathogenesis of autoimmune versus immunopathological disease.Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes.The origin and implication of thymic involution.Thymocyte selection in Vav and IRF-1 gene-deficient mice.A challenge to the instructive model of positive selection.Positive selection of immature alpha beta T cells.Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, bis(tri-n-butyltin) oxide and cyclosporine on thymus histophysiology.Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide.CD4+8- thymocytes bearing major histocompatibility complex class I-restricted T cell receptors: evidence for homeostatic control of early stages of CD4/CD8 lineage development.Synchronous deletion of Mtv-superantigen-reactive thymocytes in the CD3(medium/high) CD4(+)CD8(+) subset.Expression of an immunoglobulin heavy chain transgene in macrophage as well as lymphocyte lineages in vivo.Overexpression of the antiapoptotic protein A1 promotes the survival of double positive thymocytes awaiting positive selection.Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection
P2860
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P2860
Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh-hant
name
Distinct sequence of negative ...... yte T-cell receptor densities.
@en
Distinct sequence of negative ...... yte T-cell receptor densities.
@nl
type
label
Distinct sequence of negative ...... yte T-cell receptor densities.
@en
Distinct sequence of negative ...... yte T-cell receptor densities.
@nl
prefLabel
Distinct sequence of negative ...... yte T-cell receptor densities.
@en
Distinct sequence of negative ...... yte T-cell receptor densities.
@nl
P2093
P356
P1433
P1476
Distinct sequence of negative ...... yte T-cell receptor densities.
@en
P2093
Hengartner H
Zinkernagel RM
P2888
P304
P356
10.1038/346861A0
P407
P577
1990-08-01T00:00:00Z
P6179
1033775259