PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
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The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old ageRole of CBP and SATB-1 in aging, dietary restriction, and insulin-like signalingDeletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegansLife span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9Aging as an event of proteostasis collapseExtreme-longevity mutations orchestrate silencing of multiple signaling pathwaysStable chromatin binding prevents FoxA acetylation, preserving FoxA chromatin remodelingCross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and DiseaseMetabolic homeostasis as the cornerstone of agingPhysiological control of germline developmentGenetics and epigenetics of aging and longevityHistone methylation makes its mark on longevityRedox homeostasis in pancreatic β cellsDeactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegansFunctional loss of two ceramide synthases elicits autophagy-dependent lifespan extension in C. elegansThe MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegansHIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegansAn ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegansThe Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycinThe C. elegans Opa1 homologue EAT-3 is essential for resistance to free radicalsA role for autophagy in the extension of lifespan by dietary restriction in C. elegansThe Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signalsDietary restriction during development enlarges intestinal and hypodermal lipid droplets in Caenorhabditis elegansDietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegansFatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegansA neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespanInsulin signaling and dietary restriction differentially influence the decline of learning and memory with ageETS-4 is a transcriptional regulator of life span in Caenorhabditis elegansManipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4/FOXA in development and environmental responseEnvironmental and genetic preconditioning for long-term anoxia responses requires AMPK in Caenorhabditis elegansThe malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast.Mechanisms of aging-related proteinopathies in Caenorhabditis elegansTranscriptional and epigenetic regulation of autophagy in agingMediation of organismal aging and somatic proteostasis by the germlineTOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxORegulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinologyGenetics of aging in Caenorhabditis elegansMetformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila
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P2860
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
@en
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
@nl
type
label
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
@en
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
@nl
prefLabel
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
@en
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
@nl
P2093
P356
P1433
P1476
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
@en
P2093
Andrew Dillin
Hugo Aguilaniu
Jenni Durieux
Siler H Panowski
Suzanne Wolff
P2888
P304
P356
10.1038/NATURE05837
P407
P577
2007-05-02T00:00:00Z
P5875
P6179
1011310739