Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands.
about
The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization propertiesPositive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporterThe binding sites for cocaine and dopamine in the dopamine transporter overlapDopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addictionBehavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporterσ Receptor Effects of N-Substituted Benztropine Analogs: Implications for Antagonism of Cocaine Self-AdministrationMuscarinic preferential M(1) receptor antagonists enhance the discriminative-stimulus effects of cocaine in ratsMonoaminergic psychomotor stimulants: discriminative stimulus effects and dopamine effluxThe selective dopamine uptake inhibitor, D-84, suppresses cocaine self-administration, but does not occasion cocaine-like levels of generalization.Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats2-Substituted 3β-Aryltropane Cocaine Analogs Produce Atypical Effects without Inducing Inward-Facing Dopamine Transporter Conformations.N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effectsCitalopram enhances cocaine's subjective effects in rats.Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeysCombinations of cocaine with other dopamine uptake inhibitors: assessment of additivity.Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptorsPreference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamineDopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability.The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration.Novel C-1 substituted cocaine analogs unlike cocaine or benztropine.The binding sites for benztropines and dopamine in the dopamine transporter overlap.Role of the σRs for Development of MedicationsAssessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitorsThe novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuseDAT Conformation Does Not Predict the Ability of Atypical Dopamine Uptake Inhibitors to Substitute for Cocaine.Pharmacological characterization of a dopamine transporter ligand that functions as a cocaine antagonist.2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter.Further delineation between typical and atypical dopamine uptake inhibitors: effects on food-maintained behavior and food consumption.Addiction-related effects of DOV 216,303 and cocaine: A comparative study in the mouse.A selective dopamine reuptake inhibitor improves prefrontal cortex-dependent cognitive function: potential relevance to attention deficit hyperactivity disorder.PKC links Gq-coupled receptors to DAT-mediated dopamine release.The dopamine uptake inhibitor 3 alpha-[bis(4'-fluorophenyl)metoxy]-tropane reduces cocaine-induced early-gene expression, locomotor activity, and conditioned reward.Atypical dopamine transporter inhibitors R-modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons.Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders.The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic.Benzhexol-dependence resulting from self-medication for intermittent explosive disorder.Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays.Dopamine Transporter Dynamics of -Substituted Benztropine Analogs with Atypical Behavioral Effects
P2860
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P2860
Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Effects of N-substituted analo ...... dopamine transporter ligands.
@en
Effects of N-substituted analo ...... dopamine transporter ligands.
@nl
type
label
Effects of N-substituted analo ...... dopamine transporter ligands.
@en
Effects of N-substituted analo ...... dopamine transporter ligands.
@nl
prefLabel
Effects of N-substituted analo ...... dopamine transporter ligands.
@en
Effects of N-substituted analo ...... dopamine transporter ligands.
@nl
P356
P1476
Effects of N-substituted analo ...... dopamine transporter ligands.
@en
P2093
Gregory E Agoston
Theresa A Kopajtic
P304
P356
10.1124/JPET.103.060525
P407
P577
2004-01-30T00:00:00Z