Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent.
about
Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanismShank2 associates with and regulates Na+/H+ exchanger 3Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytesScaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complexPLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cellsNHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol.Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells.NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid.Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine.The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush border.NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells.Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation siteElevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilli.Cholinergic signaling inhibits oxalate transport by human intestinal T84 cells.Evolutionary origins of eukaryotic sodium/proton exchangers.Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid lossNHERF family and NHE3 regulation.Cell-specific effects of luminal acid, bicarbonate, cAMP, and carbachol on transporter trafficking in the intestineThe emerging role of PDZ adapter proteins for regulation of intestinal ion transport.Secretory diarrhoea: mechanisms and emerging therapies.Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration.NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.Modulation of ileal bile acid transporter (ASBT) activity by depletion of plasma membrane cholesterol: association with lipid rafts.Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis.Characterization of CFTR High Expresser cells in the intestine.Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity.NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells.Mechanisms of the regulation of the intestinal Na+/H+ exchanger NHE3NHE3 regulatory complexesRegulation of intestinal electroneutral sodium absorption and the brush border Na+/H+ exchanger by intracellular calcium.AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking.The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking.Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium.Muscarinic-induced recruitment of plasma membrane Ca2+-ATPase involves PSD-95/Dlg/Zo-1-mediated interactions.cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein.Carbachol-mediated endocytosis of NHE3 involves a clathrin-independent mechanism requiring lipid rafts and Cdc42.D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent processCardiac glycoside downregulates NHE3 activity and expression in LLC-PK1 cells.The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans.
P2860
Q24308750-ED1FBADC-24D6-4D31-A9FC-F86C44A99981Q28282331-1A565477-46E0-407E-AA3C-0594CE030882Q28508505-C2D895E3-36D9-45C5-9857-5345EBB6EE22Q28592522-BB4FDF19-2976-4529-B870-033F6B6F3E87Q33816681-EA725949-D985-45F7-87BB-7CE43F96A29EQ33931148-9702CDDD-7B4B-4982-B797-2753025760D0Q34043225-8DEE8524-36E0-4612-A108-7B84B8EF6933Q34116039-387D1D96-8EAA-4B89-916B-4E9D2E671F75Q34513510-EADB002A-6DD2-415F-8DDB-C3EB3471AA9CQ34661729-B7938371-C12D-44EC-B309-CBAA89A97C77Q34782190-796DF55E-AFC4-4CEB-BC0E-87C328E426EEQ34803046-B58E49F6-522C-40C6-ACFA-000FC7F00F7EQ35002780-0156C14F-B3C2-4D9A-8FC0-65DC719617ECQ35266484-2C3E3CC9-8AD1-4A4D-964E-85AF94304A23Q35895710-BD6EF325-4F14-4584-B58B-A747916E6F05Q36005608-DD6C2EE3-06DC-456B-9809-75FD3C205FDBQ36106076-45BCFA7D-7EC6-49BA-99AC-B0E4069D8B08Q36132944-13986366-5C60-42B6-A5F0-C62AE6576305Q36312701-2105930A-5E81-4DCB-9EB3-EEBD71E72FF2Q36518490-F09E79DD-484C-4A5B-9556-E8F59420E01FQ36673563-9DEB1EFD-978B-4CBD-A7C9-25A6EB92CA72Q36825525-AB641F7F-B79F-48ED-8487-6F327206524FQ36910196-C7E016C7-41E5-4AD4-8395-AE1AC0E61BC8Q36935074-1814F502-7990-4A79-8162-AEA3BD3C2AE7Q37098695-E347561D-EB6B-48EF-8B91-7989EF54FB70Q37142584-C15826F8-1BFD-4652-B1E8-92D261711DD5Q37339302-6CA7BDED-FE42-4B7F-BC5A-C801C32DAF2DQ37358188-F0F2F1B4-5947-47EF-95F8-97990AFAFA18Q37462304-4A4C0F73-FD52-40B6-BF95-A6EC8E63AF5EQ37485479-2E5065F5-6178-4930-AFF4-6D72E66F28FCQ37524282-EB545D11-E3B7-441B-98E5-4461FA3F90D5Q37608417-64341AE5-415D-4841-9843-C283863E1E94Q37689977-BB6471B2-EA20-4B45-8357-589D2CC22A34Q39850298-9BB3AF63-BE10-4E98-9136-548B4B1A8F81Q39914983-41124B75-0251-4B78-AB06-E0F9DB20D5FAQ40456288-A39FAEAF-BB3B-4E4D-8E16-85CF64459A25Q40544023-F79AFED3-BE02-4AE9-893B-79723A0D1280Q42586814-07BB72C5-84F9-450A-A662-37E3E989DD1CQ46849938-5B66BA8F-84E2-4A57-9328-3A895DC1EFF6Q52774162-F3E4C3A1-5957-4A3C-BCFC-AEA4C91BEF50
P2860
Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Carbachol regulation of rabbit ...... ormation and is Src dependent.
@en
Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3
@nl
type
label
Carbachol regulation of rabbit ...... ormation and is Src dependent.
@en
Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3
@nl
prefLabel
Carbachol regulation of rabbit ...... ormation and is Src dependent.
@en
Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3
@nl
P2093
P2860
P1476
Carbachol regulation of rabbit ...... ormation and is Src dependent.
@en
P2093
Alice Cheong
Christian G Elowsky
Huiping Zhang
Mark Donowitz
Sharon Leu
Yueping Chen
P2860
P304
P356
10.1113/JPHYSIOL.2004.060921
P407
P577
2004-02-20T00:00:00Z