Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion. - Wikidata - awgldk - TriplyDB

Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion.

Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion.

http://www.wikidata.org/entity/Q44824148

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Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells WFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulum Wolfram Syndrome: Diagnosis, Management, and Treatment Endoplasmic reticulum stress in the β-cell pathogenesis of type 2 diabetes Controlling complexity: the clinical relevance of mouse complex genetics WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway Expression and localization of Wolfram syndrome 1 gene in the developing rat pancreas Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice Neuroimaging evidence of deficient axon myelination in Wolfram syndrome.Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.Many faces of monogenic diabetes Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease.Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors.Neuropeptide Y expression marks partially differentiated β cells in mice and humans Wolfram syndrome in the Japanese population; molecular analysis of WFS1 gene and characterization of clinical features.Early brain vulnerability in Wolfram syndrome.Monogenic syndromes of abnormal glucose homeostasis: clinical review and relevance to the understanding of the pathology of insulin resistance and beta cell failure.Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell.A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome A WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients.Impairment of visual function and retinal ER stress activation in Wfs1-deficient mice.A review of the mammalian unfolded protein response.Selective cognitive and psychiatric manifestations in Wolfram Syndrome.Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors.The impact of the unfolded protein response on human disease Glycemic variability in patients with Wolfram syndrome is lower than in type 1 diabetes.A Challenging Form of Non-autoimmune Insulin-Dependent Diabetes in a Wolfram Syndrome Patient with a Novel Sequence Variant.Analysis of metabolic effects of menthol on WFS1-deficient mice.Circadian control of β-cell function and stress responses.Exenatide Is an Effective Antihyperglycaemic Agent in a Mouse Model of Wolfram Syndrome 1 Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits.RNA-sequencing of WFS1-deficient pancreatic islets.Phenotypic characteristics of early Wolfram syndrome Endoplasmic reticulum stress in disease pathogenesis The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes Wfs1-deficient mice display altered function of serotonergic system and increased behavioral response to antidepressants

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P2860

Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion.

http://www.wikidata.org/entity/Q44824148

description

2004 nî lūn-bûn

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Disruption of the WFS1 gene in ...... coupling in insulin secretion.

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Disruption of the WFS1 gene in ...... coupling in insulin secretion.

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Human Molecular Genetics

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Akira Tamura

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Daisuke Takei

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Hideki Katagiri

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Hiroshi Inoue

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Hiroyuki Soga

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Hisamitsu Ishihara

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Rui Takahashi

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Satoshi Takeda

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Suguru Yamaguchi

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Takahiro Yamada

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10.1093/HMG/DDH125

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11

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15056606

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