Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene.
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Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory geneFoxL2 and Smad3 coordinately regulate follistatin gene transcriptionTranscriptional regulation of steroidogenic genes: STARD1, CYP11A1 and HSD3BSUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodiesFoxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alphaThe forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout miceDysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testisConditional deletion of the retinoblastoma (Rb) gene in ovarian granulosa cells leads to premature ovarian failure.FOXL2 interacts with steroidogenic factor-1 (SF-1) and represses SF-1-induced CYP17 transcription in granulosa cells.Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter.The ovary: basic biology and clinical implicationsAromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoterHuman forkhead L2 represses key genes in granulosa cell differentiation including aromatase, P450scc, and cyclin D2Novel action of FOXL2 as mediator of Col1a2 gene autoregulation.LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity.Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ.FOXL2 in human endometrium: hyperexpressed in endometriosis.Transcriptional regulation of early oogenesis: in search of masters.Genetic analysis of the FOXL2 gene using quantitative real-time PCR in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndromeOverexpression of wild-type but not C134W mutant FOXL2 enhances GnRH-induced cell apoptosis by increasing GnRH receptor expression in human granulosa cell tumors.The Local Control of the Pituitary by Activin Signaling and Modulation.Mutant Forkhead L2 (FOXL2) proteins associated with premature ovarian failure (POF) dimerize with wild-type FOXL2, leading to altered regulation of genes associated with granulosa cell differentiation.Etiology of craniofacial malformations in mouse models of blepharophimosis, ptosis and epicanthus inversus syndrome.SNP rs1511412 in FOXL2 gene as a risk factor for keloid by meta analysis.Minireview: roles of the forkhead transcription factor FOXL2 in granulosa cell biology and pathologyRole of Foxl2 in uterine maturation and function.Potential targets of FOXL2, a transcription factor involved in craniofacial and follicular development, identified by transcriptomics.Cooperative Effects of FOXL2 with the Members of TGF-β Superfamily on FSH Receptor mRNA Expression and Granulosa Cell Proliferation from Hen Prehierarchical Follicles.FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoterNew insights into ovarian function.Cell-type specific modulation of pituitary cells by activin, inhibin and follistatin.FOXL2 down-regulates vitellogenin expression at mature stage in Eriocheir sinensisIn control of biology: of mice, men and FoxesGranulosa cell tumor mutant FOXL2C134W suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cellsThe steroidogenic acute regulatory protein as a target of endocrine disruption in male reproduction.Exploring the molecular etiology of dominant-negative mutations.The forkhead transcription factor FOXL2 is expressed in somatic cells of the human ovary prior to follicle formation.Divergent expression regulation of gonad development genes in medaka shows incomplete conservation of the downstream regulatory network of vertebrate sex determination.
P2860
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P2860
Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
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2004年學術文章
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name
Forkhead l2 is expressed in th ...... dogenic acute regulatory gene.
@en
Forkhead l2 is expressed in th ...... dogenic acute regulatory gene.
@nl
type
label
Forkhead l2 is expressed in th ...... dogenic acute regulatory gene.
@en
Forkhead l2 is expressed in th ...... dogenic acute regulatory gene.
@nl
prefLabel
Forkhead l2 is expressed in th ...... dogenic acute regulatory gene.
@en
Forkhead l2 is expressed in th ...... dogenic acute regulatory gene.
@nl
P2093
P356
P1433
P1476
Forkhead l2 is expressed in th ...... dogenic acute regulatory gene.
@en
P2093
Aaron J W Hsueh
Cynthia Klein
Jeehyeon Bae
Margareta D Pisarska
P304
P356
10.1210/EN.2003-1141
P407
P577
2004-04-01T00:00:00Z