Reconstitution and functional characterization of the unusual bi-subunit type I DNA topoisomerase from Leishmania donovani.
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Characterization of the DNA-binding domain and identification of the active site residue in the 'Gyr A' half of Leishmania donovani topoisomerase IIDifferential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I.Development of derivatives of 3, 3'-diindolylmethane as potent Leishmania donovani bi-subunit topoisomerase IB poisonsA lupane-triterpene isolated from Combretum leprosum Mart. fruit extracts that interferes with the intracellular development of Leishmania (L.) amazonensis in vitro.The effect of 3β, 6β, 16β-trihydroxylup-20(29)-ene lupane compound isolated from Combretum leprosum Mart. on peripheral blood mononuclear cells.Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitorsThe lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in miceTopoisomerases of kinetoplastid parasites: why so fascinating?Evolution and pathology in chagas disease--a review.A Novel Spirooxindole Derivative Inhibits the Growth of Leishmania donovani Parasites both In Vitro and In Vivo by Targeting Type IB TopoisomeraseEvidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant.Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776).Drug targets in Leishmania.Flavone-resistant Leishmania donovani overexpresses LdMRP2 transporter in the parasite and activates host MRP2 on macrophages to circumvent the flavone-mediated cell death.Efficacy of a Binuclear Cyclopalladated Compound Therapy for Cutaneous Leishmaniasis in the Murine Model of Infection with Leishmania amazonensis and Its Inhibitory Effect on Topoisomerase 1B.Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells.16alpha-Hydroxycleroda-3,13 (14)Z-dien-15,16-olide from Polyalthia longifolia: a safe and orally active antileishmanial agent.'LeishMan' topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani.Antileishmanial Mechanism of Diamidines Involves Targeting Kinetoplasts.Topoisomerase I gene mutations at F270 in the large subunit and N184 in the small subunit contribute to the resistance mechanism of the unicellular parasite Leishmania donovani towards 3,3'-diindolylmethane.ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism.Topoisomerase I amino acid substitutions, Gly185Arg and Asp325Glu, confer camptothecin resistance in Leishmania donovani.N-terminal region of the large subunit of Leishmania donovani bisubunit topoisomerase I is involved in DNA relaxation and interaction with the smaller subunit.The large subunit of Leishmania topoisomerase I functions as the 'molecular steer' in type IB topoisomerase.
P2860
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P2860
Reconstitution and functional characterization of the unusual bi-subunit type I DNA topoisomerase from Leishmania donovani.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
@zh-hant
name
Reconstitution and functional ...... rase from Leishmania donovani.
@en
Reconstitution and functional ...... rase from Leishmania donovani.
@nl
type
label
Reconstitution and functional ...... rase from Leishmania donovani.
@en
Reconstitution and functional ...... rase from Leishmania donovani.
@nl
prefLabel
Reconstitution and functional ...... rase from Leishmania donovani.
@en
Reconstitution and functional ...... rase from Leishmania donovani.
@nl
P2093
P2860
P1433
P1476
Reconstitution and functional ...... erase from Leishmania donovani
@en
P2093
Agneyo Ganguly
Hemanta K Majumder
Nilkantha Sen
P2860
P356
10.1016/J.FEBSLET.2004.03.078
P407
P577
2004-05-01T00:00:00Z