A structural requirement for processing the cardiac K+ channel KCNQ1. - Wikidata - awgldk - TriplyDB

A structural requirement for processing the cardiac K+ channel KCNQ1.

A structural requirement for processing the cardiac K+ channel KCNQ1.

http://www.wikidata.org/entity/Q44894427

about

The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation Structural insight into KCNQ (Kv7) channel assembly and channelopathy Crystal structure of a trimeric form of the KV7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif Novel KCNA5 mutation implicates tyrosine kinase signaling in human atrial fibrillation Regulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids.The homozygous KCNQ1 gene mutation associated with recessive Romano-Ward syndrome.Mechanisms of disease pathogenesis in long QT syndrome type 5 Emerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking.AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells.Coiled coils direct assembly of a cold-activated TRP channel.LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms.A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome.An overview of trafficking and assembly of neurotransmitter receptors and ion channels (Review).Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome.The KCNE Tango - How KCNE1 Interacts with Kv7.1.Ion channel engineering: perspectives and strategies.Molecular Pathophysiology of Congenital Long QT Syndrome.An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.Probing the mechanisms underlying modulation of quinidine sensitivity to cardiac I(Ks) block by protein kinase A-mediated I(Ks) phosphorylation.Trafficking-competent KCNQ1 variably influences the function of HERG long QT alleles.Calmodulin confers calcium sensitivity to the stability of the distal intracellular assembly domain of Kv7.2 channels.Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks.Regulation of KCNQ1/KCNE1 by β-catenin.Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations.

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P2860

A structural requirement for processing the cardiac K+ channel KCNQ1.

http://www.wikidata.org/entity/Q44894427

description

2004 nî lūn-bûn

@nan

2004年の論文

@ja

2004年学术文章

@wuu

2004年学术文章

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2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

2004年學術文章

@zh

2004年學術文章

@zh-hant

name

A structural requirement for processing the cardiac K+ channel KCNQ1.

@en

A structural requirement for processing the cardiac K+ channel KCNQ1.

@nl

type

label

A structural requirement for processing the cardiac K+ channel KCNQ1.

@en

A structural requirement for processing the cardiac K+ channel KCNQ1.

@nl

prefLabel

A structural requirement for processing the cardiac K+ channel KCNQ1.

@en

A structural requirement for processing the cardiac K+ channel KCNQ1.

@nl

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P1433

Journal of Biological Chemistry

P1476

A structural requirement for processing the cardiac K+ channel KCNQ1.

@en

P2093

Dan M Roden

http://www.w3.org/2001/XMLSchema#string

Hideaki Kanki

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Sabina Kupershmidt

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Sam Wells

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Tao Yang

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P2860

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome

Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel

Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias

Endosomal localization and function of sorting nexin 1

Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2

Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain

Role of SH3 domain-containing proteins in clathrin-mediated vesicle trafficking in Arabidopsis

Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects

Coiled coils: new structures and new functions

Setting the standards: quality control in the secretory pathway

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33976-33983

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scholarly article

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10.1074/JBC.M404539200

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32

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279

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2004-05-12T00:00:00Z

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15140888

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