Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4.
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Role of cytochrome P450 in drug interactionsGrapefruit juice-drug interactions1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues-Model Compounds Targeting Oxidative StressLack of effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of amlodipineThe effects of lacidipine on the steady/state plasma concentrations of simvastatin in healthy subjectsCloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase.Untargeted analysis of mass spectrometry data for elucidation of metabolites and function of enzymes.Metabolism-based drug interactions involving oral azole antifungals in humans.An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systemsMechanisms of pharmacokinetic and pharmacodynamic drug interactions associated with ritonavir-enhanced tipranavir.Antihypertensive therapy: special focus on drug interactions.Nevirapine in the treatment of HIV.Cytochromes P450: a structure-based summary of biotransformations using representative substrates.The enhanced atorvastatin hepatotoxicity in diabetic rats was partly attributed to the upregulated hepatic Cyp3a and SLCO1B1.Exposure-response relationships and drug interactions of sirolimusGrapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.Construction and verification of CYP3A5 gene polymorphisms using a Saccharomyces cerevisiae expression system to predict drug metabolismCYP3A5 polymorphism, amlodipine and hypertension.Hypertensive urgency after administration of a single low dose of mirtazapine-a case report.Radical cation intermediates in N-dealkylation reactions.P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer.Grapefruit juice-felodipine interaction: reproducibility and characterization with the extended release drug formulation.Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects.Pharmacokinetic interaction between ketoconazole and praziquantel in healthy volunteers.Extreme bradycardia due to multiple drug-drug interactions in a patient with HIV post-exposure prophylaxis containing lopinavir-ritonavir.In vitro activation of 7-benzyloxyresorufin O-debenzylation and nifedipine oxidation in human liver microsomes.Enhancement of nifedipine-induced gingival overgrowth by concomitant ketoconazole in rats.Pharmacokinetic interaction between efavirenz and ketoconazole in rats.Rifampicin reverses nicardipine effect inducing uncontrolled essential hypertension.Interlaboratory comparison of the assessment of P450 activities in human hepatic microsomal samples.Identification, synthesis and characterization of process related impurities of benidipine hydrochloride, stress-testing/stability studies and HPLC/UPLC method validations.Exploring PTDH-P450BM3 Variants for the Synthesis of Drug Metabolites.Lack of presystemic metabolism of nifedipine in the rabbit.In Vitro Assessment of CYP-Mediated Drug Interactions for Kinsenoside, an Antihyperlipidemic Candidate.Calcium-Channel Blockers Attenuate the Antiplatelet Effect of Clopidogrel.Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine at the Proximal Promoter
P2860
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P2860
Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh
1991年學術文章
@zh-hant
name
Oxidation of dihydropyridine c ...... liver cytochrome P-450 IIIA4.
@en
Oxidation of dihydropyridine c ...... liver cytochrome P-450 IIIA4.
@nl
type
label
Oxidation of dihydropyridine c ...... liver cytochrome P-450 IIIA4.
@en
Oxidation of dihydropyridine c ...... liver cytochrome P-450 IIIA4.
@nl
prefLabel
Oxidation of dihydropyridine c ...... liver cytochrome P-450 IIIA4.
@en
Oxidation of dihydropyridine c ...... liver cytochrome P-450 IIIA4.
@nl
P2093
P356
P1476
Oxidation of dihydropyridine c ...... liver cytochrome P-450 IIIA4.
@en
P2093
Berntsson P
Bäärnhielm C
Guengerich FP
P304
P356
10.1021/JM00110A012
P407
P577
1991-06-01T00:00:00Z