Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I. - Wikidata - awgldk - TriplyDB

Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I.

Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I.

http://www.wikidata.org/entity/Q44918045

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Synthesis and Characterization of the Arylomycin Lipoglycopeptide Antibiotics and the Crystallographic Analysis of Their Complex with Signal Peptidase Pseudomonas aeruginosa possesses two putative type I signal peptidases, LepB and PA1303, each with distinct roles in physiology and virulence Imaging mass spectrometry and genome mining via short sequence tagging identified the anti-infective agent arylomycin in Streptomyces roseosporus Subtractive genomics approach to identify putative drug targets and identification of drug-like molecules for beta subunit of DNA polymerase III in Streptococcus species.Broad-spectrum antibiotic activity of the arylomycin natural products is masked by natural target mutations In vitro activities of arylomycin natural-product antibiotics against Staphylococcus epidermidis and other coagulase-negative staphylococci Synthesis and biological characterization of arylomycin B antibiotics Initial efforts toward the optimization of arylomycins for antibiotic activity.A putative cro-like repressor contributes to arylomycin resistance in Staphylococcus aureus.Use of Metagenomics and Isolation of Actinobacteria in Brazil's Atlantic Rainforest Soil for Antimicrobial Prospecting Origins of Yersinia pestis sensitivity to the arylomycin antibiotics and the inhibition of type I signal peptidase Membrane proteases in the bacterial protein secretion and quality control pathway.Broadening the spectrum of β-lactam antibiotics through inhibition of signal peptidase type I.The inhibition of type I bacterial signal peptidase: Biological consequences and therapeutic potential.Mechanism of action of the arylomycin antibiotics and effects of signal peptidase I inhibition Exploiting quorum sensing to confuse bacterial pathogens.Efforts toward broadening the spectrum of arylomycin antibiotic activity.Screening strategies for discovery of antibacterial natural products.Signal peptidase I: cleaving the way to mature proteins.Bacterial type I signal peptidases as antibiotic targets.The biocatalytic repertoire of natural biaryl formation.Yeast: a microbe with macro-implications to antimicrobial drug discovery.Strategies for target identification of antimicrobial natural products.Not just an antibiotic target: Exploring the role of type I signal peptidase in bacterial virulence.Activity of the type I signal peptidase inhibitor MD3 against multidrug-resistant Gram-negative bacteria alone and in combination with colistin.Polishing the tarnished silver bullet: the quest for new antibiotics.Harnessing the power of transposon mutagenesis for antibacterial target identification and evaluation.New class of competitive inhibitor of bacterial histidine kinases.Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions.A practical synthesis of long-chain iso-fatty acids (iso-C12-C19) and related natural products.Quorum sensing inhibitors: can endophytes be prospective sources?Alanine scan of the peptide antibiotic feglymycin: assessment of amino acid side chains contributing to antimicrobial activity.Scalable Access to Arylomycins via C-H Functionalization Logic.Optimization of a β-Lactam Scaffold for Antibacterial Activity via the Inhibition of Bacterial Type I Signal Peptidase.

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P2860

Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I.

http://www.wikidata.org/entity/Q44918045

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I.

@en

Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I.

@nl

type

label

Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I.

@en

Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I.

@nl

prefLabel

Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I.

@en

Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I.

@nl

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Journal of Biological Chemistry

P1476

Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I.

@en

P2093

Adam J Kreuzman

http://www.w3.org/2001/XMLSchema#string

Deborah Mullen

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Eddie L Angleton

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Feng Zheng

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James R Swartling

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Kristina L Minton

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Louis N Jungheim

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Mark A Strege

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Matthew Clemens

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Matthew D Belvo

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P2860

Genome of the Bacterium Streptococcus pneumoniae Strain R6

Purification of microsomal signal peptidase as a complex

Multidrug efflux pumps of gram-negative bacteria

Mechanistic insights into the inhibition of serine proteases by monocyclic lactams

Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution

Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor

Use of T7 RNA polymerase to direct expression of cloned genes

The catalytic mechanism of endoplasmic reticulum signal peptidase appears to be distinct from most eubacterial signal peptidases.

Signal peptidases

Development of daptomycin for gram-positive infections.

P304

36250-36258

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scholarly article

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10.1074/JBC.M405884200

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35

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279

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15173160

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